Transcranial Direct Current Stimulation (tDCS) With Verb Network Strengthening Treatment (VNeST) in Chronic Aphasia

This study is testing if combining transcranial direct current stimulation (tDCS) with Verb Network Strengthening Treatment (VNeST) can improve language abilities in people with chronic aphasia (difficulty with language after a stroke). tDCS involves placing two damp sponges on your scalp and passing a weak electrical current between them to change brain activity. One sponge is placed near language areas above your left ear, and the other on your forehead above your right eye. You would receive tDCS during the first 20 minutes of your twice-weekly VNeST therapy sessions for 8 weeks. The study aims to see if this combination helps you produce more correct information in your speech. They plan to enroll 30 participants, including those with post-stroke aphasia and healthy volunteers.

Study design
This is an interventional study that plans to enroll 30 participants. It compares active tDCS with sham (inactive) tDCS during speech therapy, and the therapist will not know which type of stimulation you are receiving.
What's involved
You would complete four behavioral assessments and four brain scans (MRI). Two assessments and scans happen before treatment, one immediately after, and one 8 weeks later. Therapy sessions are 60 minutes, twice weekly for 8 weeks, and you cannot receive other speech therapy during the study (about 20 weeks).
Compensation
Not stated in the trial record.
Follow-up
Your language abilities will be assessed immediately after treatment and again 8 weeks after treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04142866

Transcranial Direct Current Stimulation (tDCS) With Verb Network Strengthening Treatment (VNeST) in Chronic Aphasia

Recruiting
NAAges 21–80InterventionalTreatment
City University of New York
~30 participants
Updated 2025-01-07 on ClinicalTrials.gov
What's tested:Anodal transcranial direct current stimulationSham transcranial direct current stimulationSpeech-Language Therapy (SLT)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Production of Correct Information Units (CIUs) on Discourse Tasks
Measured over Collected twice at baseline, immediately (<1 week) post-treatment, and at 8 week follow-up
Aphasia
Stroke

NCT04142866

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • City University of New York

    New York, New Yorkstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • E. Susan Duncan, PhD, CCC-SLP · PRINCIPAL_INVESTIGATOR · City University of New York

Opens a ready-to-send draft in your own email app — review before sending.

Want this trial checked against your situation?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Right handed (pre-stroke for participants with aphasia)
High school education or equivalent
Native English fluency without early 2nd language exposure (before age 10)
Ability to perform the required discourse and MRI tasks (determined via in-person screening)
Single-event left hemisphere stroke \> 6 months prior to enrollment
Aphasia diagnosis per Western Aphasia Battery-Revised
Not receiving any other speech therapy for the entire study period (20 weeks)
Ability to perform the required therapy tasks (determined via in-person screening)

Exclusion

Failed vision or hearing screening
MRI contraindications (including pacemaker)
Pregnancy
History of seizure or change in seizure medication in past 12 months
History of speech/language, psychiatric, or neurological disorder, or current serious medical condition (except chronic stroke comorbidities for participants with aphasia)
Unmodifiable hair style precluding scalp contact by electrodes
Sensitive scalp by self-report
  • Production of Correct Information Units (CIUs) on Discourse TasksCollected twice at baseline, immediately (<1 week) post-treatment, and at 8 week follow-up

    Change in CIU production over treatment interval. Words are counted as CIUs if they are novel, intelligible, informative, and appropriate in context (Nicholas \& Brookshire, 1993).