Continuation Study for ZEN003694 in Metastatic Castration-Resistant Prostate Cancer

This study is for people with metastatic castration-resistant prostate cancer (mCRPC), meaning prostate cancer that has spread and no longer responds to treatments that lower testosterone. It's a continuation study for those who have already participated in a ZEN003694 trial and are still benefiting from the treatment. You would continue to receive ZEN003694, possibly along with Enzalutamide. The main goal is to track any side effects (adverse events) you might experience while taking ZEN003694. To join, you must have completed a previous ZEN003694 study, be showing clinical benefit, and have a good performance status (ECOG 0 or 1).

Study design
This is an open-label, non-randomized study, meaning everyone receives the same treatment and you and your doctors will know what you are taking. It aims to enroll about 40 participants.
What's involved
You would continue to receive ZEN003694, potentially up to 120mg, and possibly Enzalutamide at 160mg. The study will monitor for side effects for up to 3 years.
Compensation
Not stated in the trial record.
Follow-up
Your treatment-related side effects will be monitored for up to 3 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04145375

Continuation Protocol for ZEN003694 in Patients Experiencing Clinical Benefit While Enrolled in a ZEN003694 Protocol

Enrolling by Invitation
PHASE1Ages 18+InterventionalTreatment
Zenith Epigenetics
~40 participants
Updated 2026-05-08 on ClinicalTrials.gov
What's tested:ZEN003694Enzalutamide

At a glance

Recruiting sites
0 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Incidence of treatment-related adverse events (AE) and treatment-related serious adverse events (SAE)
Measured over Up to 3 years
mCRPC
2 sites across 2 states
California1
Oregon1

This trial hasn't published a contact. View it on ClinicalTrials.gov

  • Incidence of treatment-related adverse events (AE) and treatment-related serious adverse events (SAE)Up to 3 years