Back to search results
NCT04151901

Sex-specific Determinants of Early-phase Recovery From Skeletal Muscle Disuse

Active, Not Recruiting
NAAges 50–65Interventional
The University of Texas Health Science Center at San Antonio
~37 participants
Updated 2026-06-04 on ClinicalTrials.gov
What's tested:Resistance Exercise RehabilitationWalking-based rehabilitation

At a glance

Recruiting sites
0 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Quantitative RNA-sequencing
Measured over Study day 1 (before starting leg disuse)
+15 more outcomes measured

Conditions

Atrophy of Muscle Due to Disuse
Rehabilitation

Explore related trials

Muscle AtrophyRehabilitation

Where it's being run

2 sites across 1 states
Texas2

Study leadership

  • Blake Rasmussen, PhD · PRINCIPAL_INVESTIGATOR · University of Texas Health Science Center as San Antonio

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

What this trial measures

  • Quantitative RNA-sequencingStudy day 1 (before starting leg disuse)

    RNA deep sequence analysis on muscle tissue taken from a muscle biopsy to measure transcriptome

  • Quantitative RNA-sequencingStudy day 7 (after finishing leg disuse)

    RNA deep sequence analysis on muscle tissue taken from a muscle biopsy to measure transcriptome

  • Quantitative RNA-sequencingStudy day 7 (after 1 bout of rehabilitation)

    RNA deep sequence analysis on muscle tissue taken from a muscle biopsy to measure transcriptome

  • Quantitative RNA-sequencingStudy day 9 (after 2 bouts of rehabilitation)

    RNA deep sequence analysis on muscle tissue taken from a muscle biopsy to measure transcriptome

  • Quantitative RNA-sequencingStudy Day 11 (after 3 bouts of rehabilitation)

    RNA deep sequence analysis on muscle tissue taken from a muscle biopsy to measure transcriptome

  • Quantitative RNA-sequencingStudy Day 21 (after finishing 7 bouts of rehabilitation)

    RNA deep sequence analysis on muscle tissue taken from a muscle biopsy to measure transcriptome

  • Muscle functionStudy day 1 (before starting leg disuse)

    Each leg will be individually tested on an isokinetic dynamometer to determine muscle strength (peak torque)

  • Muscle functionStudy day 7 (after 1 bout of rehabilitation)

    Each leg will be individually tested on an isokinetic dynamometer to determine muscle strength (peak torque)

  • Muscle functionStudy day 9 (after 2 bouts of rehabilitation)

    Each leg will be individually tested on an isokinetic dynamometer to determine muscle strength (peak torque)

  • Muscle functionStudy Day 11 (after 3 bouts of rehabilitation)

    Each leg will be individually tested on an isokinetic dynamometer to determine muscle strength (peak torque)

  • Muscle functionStudy Day 21 (after finishing 7 bouts of rehabilitation)

    Each leg will be individually tested on an isokinetic dynamometer to determine muscle strength (peak torque)

  • Body (leg) compositionStudy day 1 (before starting leg disuse)

    Leg lean mass will be assessed via segmental dual energy x-ray absorptiometry

  • Body (leg) compositionStudy day 7 (after finishing leg disuse)

    Leg lean mass will be assessed via segmental dual energy x-ray absorptiometry

  • Body (leg) compositionStudy day 9 (after 2 bouts of rehabilitation)

    Leg lean mass will be assessed via segmental dual energy x-ray absorptiometry

  • Body (leg) compositionStudy Day 11 (after 3 bouts of rehabilitation)

    Leg lean mass will be assessed via segmental dual energy x-ray absorptiometry

  • Body (leg) compositionStudy Day 21 (after finishing 7 bouts of rehabilitation)

    Leg lean mass will be assessed via segmental dual energy x-ray absorptiometry