IVIG for Autoimmune Small Fiber Neuropathy

This study is looking at whether an intravenous immunoglobulin (IVIG) called Panzyga can help people with small fiber neuropathy (SFN). SFN is a condition where the small nerves in your skin are damaged, which can cause pain. Panzyga is already approved for other conditions, but not yet for SFN. Researchers want to see if Panzyga can improve the density of nerve fibers in your skin, which will be measured through a skin biopsy. You may be able to join if you are at least 18 years old and have been diagnosed with SFN through a skin biopsy within the last year. The study aims to enroll 20 participants.

Study design
This is an interventional study, meaning participants will receive either Panzyga IVIG or a placebo. The study plans to enroll 20 participants.
What's involved
You would need to have a skin biopsy at the start of the study and again at Week 24 to measure nerve fiber density.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome is measured at Week 24, which suggests follow-up for at least 24 weeks after treatment begins.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04153422

IVIG in the Treatment of Autoimmune Small Fiber Neuropathy With TS-HDS, FGFR-3, or Plexin D1 Antibodies

Recruiting
PHASE2Ages 18+InterventionalTreatment
Endeavor Health
~20 participants
Updated 2026-01-09 on ClinicalTrials.gov
What's tested:Panzyga IVIGPlacebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
quantified change in intraepidermal nerve fiber density (IENFD)
Measured over Week 24
Small Fiber Neuropathy
Autoimmune Small Fiber Neuropathy
Inflammatory Polyneuropathy
Immune-Mediated Neuropathy
1 sites across 1 states
Illinois1
  • Lawrence Zeidman, MD, FAAN · PRINCIPAL_INVESTIGATOR · Endeavor Health

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  • quantified change in intraepidermal nerve fiber density (IENFD)Week 24

    3mm skin punch biopsy at 3 sites