Cerebral Oxygen Metabolism in Children with Sickle Cell Disease and Stroke
This study aims to understand how blood flow and metabolism affect brain development in children and young adults, especially those with Sickle Cell Disease or a history of stroke. Researchers will use magnetic resonance imaging (MRI) to measure how the brain's blood vessels expand and contract. During the MRI, participants will inhale carbon dioxide to see how their blood vessels react. The main goal is to measure your brain's oxygen metabolism during this 75-minute MRI scan. This research hopes to find ways to identify brain tissue at risk of permanent injury. The study is currently recruiting 350 participants, including healthy individuals.
- Study design
- This is an interventional study with a planned enrollment of 350 participants. It is not specified if it is randomized or blinded.
- What's involved
- You would participate in an MRI scan where you inhale carbon dioxide. The MRI scan itself will last about 75 minutes.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary measurement of cerebral oxygen metabolism occurs during the 75-minute MRI scan. No further follow-up is specified.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Cerebral Oxygen Metabolism in Children
At a glance
Conditions
NCT04157179
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
Washington University of St. Louis
St Louis, Missouristudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Cerebral Oxygen MetabolismFrom the beginning of the MRI scan to the completion of the MRI scan -- 75 minutes.