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Understanding Medication Levels in Chronic or Infectious Diseases

This observational study is looking at new ways to measure medication levels in people with chronic (long-lasting) or infectious diseases. Researchers want to see if they can accurately measure levels of medications like cyclophosphamide, mycophenolic acid, mycophenolate mofetil, metformin, or busulfan in sweat and saliva, compared to traditional blood tests. They are also testing a smart wristband to see if it can accurately measure chemicals in sweat. The goal is to find easier, home-based ways to check medication levels. You can join if you are 18 or older, have a chronic or infectious disease, and are taking one of the listed medications. The study aims to see how well these new methods predict medication concentrations within 4 hours.

Study design
This is an observational study planning to enroll 100 participants. It compares different methods of measuring medication levels without assigning specific treatments.
What's involved
You would provide sweat, saliva, and blood samples within 24 hours of taking your medication. You would also complete a short questionnaire (5-10 minutes) and allow researchers to review your medical chart.
Compensation
Not stated in the trial record.
Follow-up
After completing the study procedures, patients are followed up periodically.

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NCT04160429

Biospecimen Analysis in Detecting Chemical Concentrations in Patients With Chronic or Infectious Diseases Receiving Meditations

Recruiting
Not specifiedAges 18+Observational
City of Hope Medical Center
~100 participants
Updated 2025-11-10 on ClinicalTrials.gov
What's tested:Biospecimen CollectionMedical Chart ReviewQuestionnaire Administration

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Predictive performance of the home-based sampling
Measured over Up to 4 hours
+1 more outcome measured

Conditions

Chronic Disease
Infectious Disorder

Explore related trials

Chronic DiseaseInfectious Disorder

Where it's being run

1 sites across 1 states
California1

Study leadership

  • Jeannine S McCune · PRINCIPAL_INVESTIGATOR · City of Hope Medical Center

Who to contact

Jeannine S. McCune
[email protected]
626-218-4611
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Scheduled to receive medications including, but not limited to, cyclophosphamide, mycophenolic acid, mycophenolate mofetil, metformin or busulfan (any dose, any number of doses, any dosing frequency) as part of treatment at any time. Patients with chronic or infectious diseases can participate
Willingness to:
Provide blood, sweat, and saliva samples
Permit medical record review

Exclusion

Pilocarpine allergy
Difficulty with understanding written English

What this trial measures

  • Predictive performance of the home-based samplingUp to 4 hours

    Will be assessed by Pearson correlation and quantification of the predictive performance. The predictive performance of the home-based sampling methods will be assessed by calculating the median percentage prediction error (MPPE).

  • Observed plasma concentrationsUp to 4 hours

    Will be assessed by Pearson correlation and quantification of the predictive performance. The values from plasma will be considered the observed concentration.