Blood Pressure Slopes and Ultrafiltration in Hemodialysis Patients

This study is testing a new way to manage fluid removal during hemodialysis (a treatment for kidney failure) called IBPS-Guided Ultrafiltration. The goal is to reduce extra body fluid without causing dangerous drops in blood pressure during dialysis. Researchers will look at your blood pressure patterns during dialysis and use a special plan to decide how much fluid to remove. This study is for people aged 18 and older who are on hemodialysis and have high blood pressure either before or after their dialysis sessions. The main goal is to see if this new approach can improve your systolic blood pressure (the top number in a blood pressure reading) after 4 months.

Study design
This is an interventional study planning to enroll 69 participants. It is not specified if it is randomized or blinded.
What's involved
Each month, a study investigator will review your average blood pressure patterns from the prior two weeks to adjust fluid removal.
Compensation
Not stated in the trial record.
Follow-up
Your ambulatory systolic blood pressure will be measured at 4 months.

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NCT04163614

Blood Pressure Slopes and Ultrafiltration in Hemodialysis Patients

Recruiting
NAAges 18+InterventionalTreatment
VA Office of Research and Development
~69 participants
Updated 2026-07-20 on ClinicalTrials.gov
What's tested:IBPS-Guided Ultrafiltration

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Ambulatory Systolic Blood Pressure
Measured over 4 months
End Stage Renal Disease
Hypertension
Extracellular Volume Overload
Intradialytic Hypotension
1 sites across 1 states
Texas1
  • Peter Noel Van Buren, MD · PRINCIPAL_INVESTIGATOR · VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX

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Eligibility criteria

Inclusion

Hemodialysis patient
Pre-dialysis systolic blood pressure greater than 140 mmHg averaged over 2 weeks OR post-dialysis systolic blood pressure greater than 130 mmHg averaged over 2 weeks

Exclusion

HemoDialysis Vintage Less than 2 months
Pregnancy
Mean systolic blood pressure nadir \<95 mmHg in 2 weeks screening
Mean pre- or post-dialysis systolic blood pressure \>180 mmHg
Mean pre to post-HD decrease in blood pressure \>60 mmHg
Routine intradialytic clonidine use
Routine intradialytic midodrine use
Documented antihypertensive medication non-adherence
Mean ultrafiltration rate \>13 mL/kg/hr during 2 week screening
For bioimpedance measurements only: amputation of a major extremity, presence of cardiac defibrillator or pacemaker, presence of a metallic implant (prosthetic joint)
  • Ambulatory Systolic Blood Pressure4 months

    Will compare between-group difference in change in ambulatory systolic blood pressure from baseline to 4-month follow up