Hyperinflation Respiratory Therapies After Cardiac Surgery

This study is looking at different breathing treatments to help your lungs recover after heart surgery. It compares three types of respiratory therapies: EzPAP, Metaneb, and Intermittent Positive Pressure Breathing (IPPB). These therapies help expand your lungs and prevent problems like lung collapse after surgery. Researchers want to see which therapy works best to improve your lung function, specifically how much air you can breathe out forcefully (FEV1/FVC). You might be able to join if you are between 18 and 80 years old, had certain heart surgeries through a chest incision, and are admitted to the Cardiovascular ICU. The study aims to enroll 324 participants.

Study design
This is an interventional study where participants are randomly assigned to one of three respiratory therapies. It plans to enroll 324 participants.
What's involved
You would receive 10 minutes of your assigned respiratory therapy four times daily. This would continue for up to 96 hours post-surgery or until discharge from the ICU.
Compensation
Not stated in the trial record.
Follow-up
Your lung function will be assessed for up to 96 hours after surgery or until you are discharged from the intensive care unit (ICU), whichever comes first.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04164173

Hyperinflation Respiratory Therapies in Cardiac Surgery Patients

Recruiting
NAAges 18–80InterventionalPrevention
University of Texas Southwestern Medical Center
~324 participants
Updated 2025-11-04 on ClinicalTrials.gov
What's tested:EzPAPMetanebIntermittent Positive Pressure Breathing (IPPB)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Postoperative lung function as assessed by the changes in FEV1/FVC
Measured over Up to 96 hours postoperatively or until discharge from the intensive care unit (ICU), whichever came first.
Pulmonary Disease
Postoperative Complications
1 sites across 1 states
Texas1
  • Jaffer Odeh, MD · STUDY_CHAIR · University of Texas Southwestern Medical Center

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  • Postoperative lung function as assessed by the changes in FEV1/FVCUp to 96 hours postoperatively or until discharge from the intensive care unit (ICU), whichever came first.

    The postoperative changes in the Forced Expiratory Volume in one second (FEV1)/the Forced Vital Capacity (FVC) in microspirometry