This study, called the GETSET trial, is looking at whether a procedure called Preimplantation Genetic Testing for Aneuploidy (PGT-A) can improve pregnancy rates for women aged 35 to 40 who are undergoing In Vitro Fertilization (IVF). PGT-A involves screening embryos for chromosome abnormalities before they are transferred. We want to see if transferring a single embryo that has been tested and found to be normal (euploid) leads to more ongoing pregnancies compared to transferring an untested embryo. The study plans to enroll 240 women who are undergoing IVF with Intracytoplasmic Sperm Injection (ICSI) using their own or donor sperm. The main goal is to measure the ongoing pregnancy rate up to 18 months after the embryo transfer.

Study design

This is a randomized controlled trial, meaning participants will be assigned by chance to either receive PGT-A or not. A total of 240 women will participate, split evenly between two IVF centers.

What's involved

You would undergo standard IVF procedures including ovarian hyper-stimulation, egg retrieval, fertilization, and embryo culture. Depending on your assigned group, your embryos may undergo a biopsy for PGT-A.

Compensation

Not stated in the trial record.

Follow-up

Your pregnancy outcome will be followed for up to 18 months after the embryo transfer.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.