The Youth Opioid Recovery Support (YORS) Intervention for Opioid-use Disorder

This study is testing a program called Youth Opioid Recovery Support (YORS) for young adults with opioid-use disorder (OUD). The YORS program is designed to help young people stay engaged in treatment and take their medications as prescribed. It includes things like home delivery of medications (extended release naltrexone or XR-NTX, and extended release buprenorphine or XR-BUP), involving family in treatment, and using text messages and social media to stay in touch. The study aims to enroll 150 participants. Success will be measured by how many medication injections you receive and how often opioid relapse (using opioids again) occurs over 26 weeks. You may be able to join if you are 18-28 years old, have an OUD diagnosis, plan to receive treatment with XR-NTX or XR-BUP, and are willing to have a family member or other important person involved in your treatment. The current recruitment status is unclear.

Study design
This is an interventional study with a planned enrollment of 150 participants. The study aims to refine the YORS intervention through stakeholder input and pilot iterative testing followed by an efficacy randomized controlled trial.
What's involved
You would receive injections of MOUD (Medication for Opioid Use Disorder) like XR-NTX or XR-BUP. Data on opioid relapse will be collected every two weeks for 26 weeks.
Compensation
Not stated in the trial record.
Follow-up
Your progress will be monitored for 26 weeks, with data collected every two weeks during that period.

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NCT04173416

The Youth Opioid Recovery Support (YORS) Intervention

Recruiting
NAAges 18–28InterventionalTreatment
Potomac Health Foundations
~150 participants
Updated 2025-09-24 on ClinicalTrials.gov
What's tested:Youth Opioid Recovery Support (YORS)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Number of MOUD injections received (XR-NTX or XR-BUP)
Measured over Treatment week 0 to 26 weeks
+1 more outcome measured
Opioid-use Disorder
Medication Adherence
1 sites across 1 states
Maryland1
  • Marc Fishman, MD · PRINCIPAL_INVESTIGATOR · Maryland Treatment Centers, Inc.

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Eligibility criteria

Inclusion

Age 18-28
OUD diagnosis
Willing (intending) to receive treatment with XR-NTX or XR-BUP under the care of a MTC physician/nurse practitioner
Willingness to designate family member (or other suitable treatment significant other) for treatment involvement (i.e., a treatment significant other; TSO)

Exclusion

Psychiatric or medical instability (e.g., suicidality, psychosis, Sickle Cell disease with frequent crises) that would preclude participation in the trial
Living situation (location greater than 75 miles from the center, homelessness) that would preclude participation in the trial
  • Number of MOUD injections received (XR-NTX or XR-BUP)Treatment week 0 to 26 weeks

    Total number of injections received within 26 weeks

  • Rate of opioid relapse during the study periodTime Frame: Data measured every 2 weeks for the duration of the 26-week study period

    Relapse = 10 days of use within a 28 day period. Days of opioid use will be assessed through urine toxicology and self report methods.