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Nasal Inhalation of Isopropyl Alcohol for Nausea in Cancer Patients

This study is looking into whether inhaling Isopropyl Alcohol can help reduce nausea in cancer patients. You might be able to join if you are an adult cancer patient experiencing moderate to severe nausea (rated 4 or higher on a 0-10 scale) and can read and write in English. The study will compare Isopropyl Alcohol inhalation to a placebo (an inactive substance that looks like the study solution). Researchers will measure changes in your nausea levels within 5 minutes after you inhale the study solution or placebo. The study aims to enroll 112 participants, but its current recruitment status is unclear.

Study design
This interventional study will compare Isopropyl Alcohol inhalation to a placebo in 112 participants. It is designed to see if Isopropyl Alcohol has a real effect on nausea.
What's involved
You would inhale either Isopropyl Alcohol or a placebo from a preparation pad. You would also complete questionnaires, including rating your nausea and anxiety levels.
Compensation
Not stated in the trial record.
Follow-up
Your nausea will be measured up to 5 minutes after the intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04181463

Nasal Inhalation of Isopropyl Alcohol for the Treatment of Nausea in Patients With Cancer

Not Yet Recruiting
PHASE2Ages 18+InterventionalTreatment
M.D. Anderson Cancer Center
~112 participants
Updated 2026-05-27 on ClinicalTrials.gov
What's tested:Isopropyl AlcoholPlaceboQuestionnaire Administration

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in nausea
Measured over Baseline up to 5 minutes post-intervention

Conditions

Malignant Neoplasm

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Malignant Neoplasm

Where it's being run

1 sites across 1 states
Texas1

Study leadership

  • Yvonne J Heung · PRINCIPAL_INVESTIGATOR · M.D. Anderson Cancer Center

Who to contact

Michael J Tang, MD
[email protected]
(832) 468-8895
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Rate current severity of acute/chronic nausea \>= 4 on NRS (Numeric Rating Scale)
Diagnosis of cancer
Able to read/write in English
Referred to supportive care service as an inpatient or outpatient
Rate anxiety as =\< 4 on ESAS-FS (Edmonton Symptom Assessment Scale-Financial Distress and Spiritual Pain)
Participants must agree to inhale isopropyl alcohol

Exclusion

Received anti-emetics in the last 30 minutes
Received medical procedures (e.g. blood draws) which required exposure of isopropyl alcohol in the last 30 minutes
Inability to inhale through nares (including recent upper respiratory infection)
Known allergy to isopropyl alcohol
Delirium (i.e., score \>= 7 on the Memorial Delirium Assessment Scale \[MDAS\])
Have never been on anti-emetics during the course of the treatment here (anti-emetic naive)

What this trial measures

  • Change in nauseaBaseline up to 5 minutes post-intervention

    The mean change in nausea level will be compared between the two arms by two sample t-test. In case there's any violation in the underlying assumptions (e.g. normality, equality of variance, etc.) proper transformation (e.g. logarithm, square root, etc.) or non-parametric methods (Wilcoxon rank sum test) will be applied.