AI-CRIC Study: Understanding Kidney and Heart Disease in American Indians

This observational study, called the American Indian Chronic Renal Insufficiency Cohort Study (AI-CRIC), aims to better understand chronic kidney disease (CKD) and heart disease in American Indian communities. Researchers want to identify unique risk factors for these conditions and compare how they progress in American Indians versus other populations. You might be eligible if you are between 21 and 80 years old and have certain levels of kidney function (eGFR of 61-80 with microalbuminuria, or eGFR of 60 or less). The study will look at how your kidney function changes over 5 years. The current status of this study is unclear.

Study design
This is an observational study planning to enroll 500 participants. It does not involve a specific intervention or drug.
What's involved
You will have an initial clinic visit lasting 1-2 hours, which includes measurements, blood draws, urine collection, and questionnaires. You will also have phone calls six months after your first visit and annual follow-up visits.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed annually, and the primary endpoint for kidney function change is measured at 5 years.

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NCT04185844

American Indian Chronic Renal Insufficiency Cohort Study (AI-CRIC Study)

Recruiting
Not specifiedAges 21–80Observational
University of New Mexico
~500 participants
Updated 2026-05-20 on ClinicalTrials.gov

At a glance

Recruiting sites
2 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Slope of the GFR
Measured over 5 years
Diabetes Mellitus
Chronic Kidney Diseases
Heart Diseases
Cardiovascular Diseases
3 sites across 2 states
New Mexico2
Arizona1
  • Mark L Unruh, MD · PRINCIPAL_INVESTIGATOR · University of New Mexico

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Eligibility criteria

Inclusion

Glomerular Filtration Rate (GFR): eGFR of =\>61\<80 and microalbuminuria \> 30 or eGRF of =\<60 (no microalbuminuria required).
  • Slope of the GFR5 years

    Primary outcomes regarding Cardio vascular disease will focus on clinical events indicative of ischemic heart disease, CHF, stroke, and peripheral vascular disease supplemented by radiographic evidence of progressive CVD.