Surgical Treatment for Cervical Deformity Study

This study is looking at how well surgery works for people with cervical deformity (a problem with the natural curve of your neck). It's an observational study, meaning researchers will follow patients who are already getting surgery for this condition. The goal is to see how surgery affects pain in the head, neck, and arms over time. You might be able to join if you are at least 18 years old and have a diagnosis of cervical deformity, which includes specific measurements of neck curvature. Researchers plan to include about 200 people in this study. The current status of this study is unclear.

Study design
This is an observational study, meaning researchers will follow patients who are already receiving surgical treatment. It aims to include about 200 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for up to 10 years after surgery, with check-ups at 3 months, 6 months, and 1, 2, 5, and 10 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04194996

Radiographic and Clinical Evaluation of Surgical Treatment for Cervical Deformity: A Multi-Center Study 2.0

Recruiting
Not specifiedAges 18+Observational
International Spine Study Group Foundation
~200 participants
Updated 2026-02-17 on ClinicalTrials.gov
What's tested:Surgical intervention

At a glance

Recruiting sites
13 of 16 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Pain Numeric rating scale (NRS) - Headaches
Measured over Change from Preop to 3 months, 6 months and 1, 2, 5 & 10 year follow-up
+14 more outcomes measured
Cervical Deformity

NCT04194996

Where you'd take part

This study runs at 16 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Columbia University Medical Center

    New York, New Yorkstudy coordinator listed

    Recruiting

  • Denver International Spine Center, Rocky Mountain Hospital for Children and Presbyterian St. Luke's Medical Center

    Denver, Coloradostudy coordinator listed

    Recruiting

  • Duke University Health System

    Durham, North Carolinastudy coordinator listed

    Recruiting

  • Hospital for Special Surgery, Department of Orthopedic Surgery

    New York, New Yorkstudy coordinator listed

    Recruiting

  • Johns Hopkins University, Department of Neurological Surgery

    Baltimore, Marylandstudy coordinator listed

    Recruiting

  • Leatherman Spine Center, Department of Orthopedic Surgery

    Louisville, Kentuckystudy coordinator listed

    Recruiting

  • Medical City Spine Hospital - Southwest Scoliosis Institute

    Dallas, Texasstudy coordinator listed

    Recruiting

  • New York University, Department of Orthopedic Surgery

    New York, New Yorkstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Justin Smith, MD · PRINCIPAL_INVESTIGATOR · University of Virginia, Department of Neurosurgery
  • Christopher Ames, MD · PRINCIPAL_INVESTIGATOR · University of California, San Francisco, Department on Neurosurgery
  • Christopher I Shaffrey, MD · PRINCIPAL_INVESTIGATOR · Duke University, Departments of Neurosurgery and Orthopaedic Surgery

Opens a ready-to-send draft in your own email app — review before sending.

Want this trial checked against your situation?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

≥18 years old at time of treatment
Diagnosis of cervical deformity- must meet one or more of the following criteria:
C2-C7 sagittal kyphosis (Cobb \> 15 degrees)
T1S-CL \> 35o
Segmental cervical kyphosis \> 10 degrees between any 2 vertebra between C2-T1 or \> 15 degrees across any 3 vertebra between C2-T1
Cervical scoliosis \> 10 degrees (Cobb angle must include end vertebra within the cervical spine)
C2-C7 SVA \> 4cm
McGregor's slope \> 20 degrees or CBVA \> 25 degrees OR
Planned Revision surgery for proximal junctional failure with an anticipated UIV in the cervical spine and an anticipated LIV in the thoracic or lumbar spine.
Plan for surgical correction of cervical deformity in the next 6 months
Willing to provide consent and complete study forms at baseline and follow-up intervals
Upright AP/Lateral entire spine (EOS or 36")
Upright AP/Lateral C spine ONLY IF C spine is not completely visible on entire spine films
Flex/Ext lateral C spine. Admin may allow exceptions w/ valid documentation.

Exclusion

Active spine tumor or infection
Deformity due to acute trauma
Unwilling to provide consent or to complete study forms
Prisoner
Pregnant or immediate plans to get pregnant
  • Pain Numeric rating scale (NRS) - HeadachesChange from Preop to 3 months, 6 months and 1, 2, 5 & 10 year follow-up

    Self-reported pain in Head where 0=no pain/10=severe pain

  • Pain Numeric rating scale (NRS) - NeckChange from Preop to 3 months, 6 months and 1, 2, 5 & 10 year follow-up

    Self-reported pain in Neck where 0=no pain/10=severe pain

  • Pain Numeric rating scale (NRS) - Upper extremityChange from Preop to 3 months, 6 months and 1, 2, 5 & 10 year follow-up

    Self-reported pain in Arms where 0=no pain/10=severe pain

  • Pain Numeric rating scale (NRS) - Lower extremityChange from Preop to 3 months, 6 months and 1, 2, 5 & 10 year follow-up

    Self-reported pain in Legs where 0=no pain/10=severe pain

  • Pain Numeric rating scale (NRS) - BackChange from Preop to 3 months, 6 months and 1, 2, 5 & 10 year follow-up

    Self-reported pain in Back where 0=no pain/10=severe pain

  • Neck Disability Index (NDI)Change from Preop to 3 months, 6 months and 1, 2, 5 & 10 year follow-up

    Patient reported neck disability tool

  • Veterans RAND 12 Item Health Survey (VR-12)Change from Preop to 3 months, 6 months and 1, 2, 5 & 10 year follow-up

    Patient reported outcome

  • Patient-Reported Outcome Measurement Information System (PROMIS) - AnxietyChange from Preop to 3 months, 6 months and 1, 2, 5 & 10 year follow-up

    Computer adaptive PROs

  • Patient-Reported Outcome Measurement Information System (PROMIS) - DepressionChange from Preop to 3 months, 6 months and 1, 2, 5 & 10 year follow-up

    Computer adaptive PROs

  • Patient-Reported Outcome Measurement Information System (PROMIS) - Pain InterferenceChange from Preop to 3 months, 6 months and 1, 2, 5 & 10 year follow-up

    Computer adaptive PROs

  • Patient-Reported Outcome Measurement Information System (PROMIS) - Physical FunctionChange from Preop to 3 months, 6 months and 1, 2, 5 & 10 year follow-up

    Computer adaptive PROs

  • Patient-Reported Outcome Measurement Information System (PROMIS) - Social Satisfaction (Role)Change from Preop to 3 months, 6 months and 1, 2, 5 & 10 year follow-up

    Computer adaptive PROs

  • Patient-Reported Outcome Measurement Information System (PROMIS) - Social Satisfaction (DSA)Change from Preop to 3 months, 6 months and 1, 2, 5 & 10 year follow-up

    Computer adaptive PROs

  • Spine RadiographsChange from Preop to 3 months, 6 months and 1, 2, 5 & 10 year follow-up

    Radiographic parameters (Cervical lordosis, Kyphosis, Scoliosis; Global balance in coronal and sagittal planes of the spine; pelvic parameters (pelvic incidence, tilt, slope) and bony fusion status.

  • Modified Japanese Orthopaedic Association Scale (mJOA)Change from Preop to 3 months, 6 months and 1, 2, 5 & 10 year follow-up

    Patient reported outcome measuring functional status using scale of 0 to 18. The higher the score, the less disability.