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Evaluating Glial Acetate Metabolism for Hypoglycemia Prediction

This study is looking for healthy volunteers aged 18-40 to help understand how the brain's glial cells use acetate, a simple chemical, and if this process can predict low blood sugar (hypoglycemia) in people with diabetes. Researchers will use a special imaging technique called carbon-13 magnetic resonance spectroscopy (13C-MRS) while giving participants a labeled form of acetate (13C-acetate) through an IV. They will also carefully lower blood sugar levels using insulin and glucose infusions. The main goal is to see if measuring the amount of 13C in bicarbonate in the brain, every ten minutes for two hours after acetate is given, can show how well the body responds to low blood sugar. This study is currently unclear on its recruitment status and plans to enroll 10 participants.

Study design
This interventional study plans to enroll 10 healthy participants. It is not specified if it is randomized or blinded.
What's involved
You would receive infusions of insulin, glucose, and 13C-acetate through IVs. Blood samples would be drawn, and you would undergo a 13C-MRS procedure.
Compensation
Not stated in the trial record.
Follow-up
The primary measurement of 13C enrichment is taken every ten minutes for 120 minutes following 13C-acetate administration.

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NCT04207619

Evaluating Glial Acetate Metabolism as a Biomarker of Hypoglycemic Counterregulation

Recruiting
NAAges 18–40InterventionalBasic science
Pennington Biomedical Research Center
~10 participants
Updated 2025-07-24 on ClinicalTrials.gov
What's tested:hyperinsulinemic-hypoglycemic clamp13C-MRS procedure/Acetate infusion

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percent 13C enrichment of bicarbonate measured via carbon-13 magnetic resonance spectroscopy (13C-MRS)
Measured over Every ten minutes for 120 minutes following administration of 1-13C acetate

Conditions

Diabetes
Hypoglycemia

Explore related trials

Diabetes MellitusHypoglycemia

Where it's being run

1 sites across 1 states
Louisiana1

Study leadership

  • David McDougal, PhD · PRINCIPAL_INVESTIGATOR · PBRC

Who to contact

Amber Dragg
[email protected]
225-763-3050
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Healthy male or female
Ages 18-40 years
BMI between 20 kg/m2 and 30 kg/m2 (±0.5 kg/m2 will be accepted)
Medically cleared for participation in the study

Exclusion

Contraindication to MRI
Consume \>10 alcoholic drinks/week
History of chronic smoking or have quit less than 10 years ago
History of clinically diagnosed diabetes or a fasting blood glucose \>126 mg/dL
Average screening blood pressure \>140/90 mmHg
History of cardiovascular disease
Pregnant, planning to become pregnant, or breastfeeding
Use of medications affecting glucose metabolism, e.g., benzodiazepines, thiazide diuretics, cortisone, and prednisone.
Use of beta-adrenergic antagonists.
Based on the investigative team's clinical judgement, a subject may not be appropriate for participation in the study.

What this trial measures

  • Percent 13C enrichment of bicarbonate measured via carbon-13 magnetic resonance spectroscopy (13C-MRS)Every ten minutes for 120 minutes following administration of 1-13C acetate

    Glial acetate metabolism