Understanding Advanced Medullary Thyroid Cancer

This observational study aims to understand how advanced medullary thyroid cancer (MTC) develops and progresses. Researchers will collect information from a registry to learn about the natural course of MTC, including how it affects patients' experiences and quality of life. They will also look at how certain measurements and patient-reported information relate to the use and effectiveness of targeted therapies. This study is for adults diagnosed with MTC, particularly those with advanced disease (Stage III or IV). The goal is to gather information for up to four years to help improve how advanced MTC is managed. The current recruitment status is unclear.

Study design
This is an observational study planning to enroll 2030 participants. It is not a treatment study, but rather gathers information about the disease.
What's involved
Participants will undergo blood pressure measurements and complete questionnaires. This information will be collected for up to 4 years.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for up to 4 years to track the natural history of MTC and their experiences.

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NCT04216732

Natural History of Medullary Thyroid Cancer to Inform Advanced Disease Management

Recruiting
Not specifiedAges 18+Observational
M.D. Anderson Cancer Center
~2,030 participants
Updated 2026-03-05 on ClinicalTrials.gov
What's tested:Blood Pressure MeasurementQuestionnaire Administration

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Natural history of medullary thyroid cancer (MTC)
Measured over Up to 4 years
+2 more outcomes measured
Advanced Thyroid Gland Medullary Carcinoma
Stage III Thyroid Gland Medullary Carcinoma AJCC v8
Stage IV Thyroid Gland Medullary Carcinoma AJCC v8
Stage IVA Thyroid Gland Medullary Carcinoma AJCC v8
Stage IVB Thyroid Gland Medullary Carcinoma AJCC v8
Stage IVC Thyroid Gland Medullary Carcinoma AJCC v8
2 sites across 2 states
California1
Texas1
  • Elizabeth G Grubbs · PRINCIPAL_INVESTIGATOR · M.D. Anderson Cancer Center

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Eligibility criteria

Inclusion

Aims 1 and 2: A diagnosis of MTC
Aims 1 and 2: A registrant in the Medullary Thyroid Cancer Registry (MTCR). Patients of all disease phases will be eligible for enrollment
Aim 3: A diagnosis of advanced phase (red or gray) MTC as determined by clinical team
Aim 3: A current registrant in the MTCR
  • Natural history of medullary thyroid cancer (MTC)Up to 4 years

    Will describe the natural history of MTC using comprehensive battery of demographic, clinical, pathologic, and genotypic variables collected in existing multi-institutional patient registry.

  • Patients' experience with the different phases of MTCUp to 4 years

    Will characterize patients' experience with the different phases of MTC through a systematic evaluation of patient-reported outcomes (PROs).

  • Association of selected biometric and patient-reported outcomesUp to 4 years

    Will evaluate the association of selected biometric and patient-reported outcomes on adherence, change, and discontinuation of approved targeted therapies and drugs being tested within clinical trial.