This study is looking at how a very low carbohydrate diet (ketogenic diet) affects brain function in people with type 1 diabetes (T1D). Researchers want to understand if this diet can help your brain tolerate low blood sugar (hypoglycemia) better. You might be able to join if you are 18-40 years old, have had T1D for at least a year, use an insulin pump and continuous glucose monitor (CGM), and have stable blood sugar control (HbA1c between 6.5-9%). The study will compare a very low carbohydrate diet to a standard carbohydrate diet. Success will be measured by seeing if the ketogenic diet changes the blood sugar level at which a part of your brain called the hypothalamus becomes active during low blood sugar. The current status of this study is unclear.

Study design

This is an interventional study that will involve 24 participants with type 1 diabetes. Participants will be randomly assigned to either a very low carbohydrate diet or a standard carbohydrate diet for 12 weeks.

What's involved

Participants will have all meals delivered and will eat only study foods. You will also receive supplements and have your diet adjusted for satiety. The study involves insulin infusions, neuroimaging (MRI), and assessments of blood levels, reaction time, and cognitive performance.

Compensation

Not stated in the trial record.

Follow-up

The primary endpoint, glycemic threshold for hypothalamic activation, is measured between week 5 and 12 of the diet.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.