PROVE Trial: Weight Loss and Exercise for Peripheral Artery Disease
This study, called the PROVE Trial, is looking at whether combining a weight loss program with walking exercise can better improve or slow the decline in walking ability for people with peripheral artery disease (PAD) and a BMI (Body Mass Index) over 25 kg/m2. The weight loss program includes coaching, mobile technology, and a special diet. You could join if you are at least 18 years old, have PAD (diagnosed by specific ankle or toe blood pressure readings), and a BMI over 25. The main goal is to see how far participants can walk in six minutes after 12 months.
- Study design
- This is a randomized clinical trial with 212 participants. You would be assigned to either a group receiving weight loss support plus exercise, or a group receiving exercise alone.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for 12 months to measure changes in their six-minute walk distance.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Promote Weight Loss in Obese Peripheral Artery Disease (PAD) Patients to Prevent Mobility Loss
At a glance
Conditions
Where it's being run
7 sites across 6 statesStudy leadership
- Mary M McDermott, MD · PRINCIPAL_INVESTIGATOR · Northwestern University
- Walter Ambrosius, PhD · PRINCIPAL_INVESTIGATOR · Wake Forest University
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- 12-month change in six-minute walk distanceBaseline to 12 months
Change in six-minute walk distance at 12-month follow-up will be compared between individuals randomized to weight loss + exercise vs. those randomized to exercise alone.