Understanding Brain Blood Flow with Respiratory Challenges

This study aims to understand how blood flow and metabolism (how your body uses energy) differ in the brain between healthy individuals and those with brain vascular (blood vessel) conditions. Researchers will use magnetic resonance imaging (MRI) to examine brain blood flow while you breathe in different air mixtures, including air with added carbon dioxide. The main goal is to measure how much oxygen your brain uses during the MRI scan, which lasts about 75 minutes. You may be eligible if you are a healthy adult or an adult with a brain vascular condition, are at least 18 years old, can have an MRI without sedation, are not on stimulant medications, and have no history of psychiatric treatment.

Study design
This interventional study plans to enroll 48 participants. It is not specified if participants will be randomly assigned to groups or if the study is blinded.
What's involved
You would participate in an MRI scan where you will inhale carbon dioxide. The MRI scan and oxygen metabolism measurement will take about 75 minutes.
Compensation
Not stated in the trial record.
Follow-up
The primary measurement of cerebral oxygen metabolism occurs from the beginning to the completion of the 75-minute MRI scan.

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NCT04258774

The Effect of Respiratory Challenge on the BOLD Signal

Enrolling by Invitation
NAAges 18+Interventional
Washington University School of Medicine
~48 participants
Updated 2026-01-16 on ClinicalTrials.gov
What's tested:Carbon Dioxide

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Cerebral Oxygen Metabolism
Measured over From the beginning of the MRI scan to the completion of the MRI scan -- 75 minutes.
Hypoxia, Brain
Hyperoxia
Hypercapnia
Hypocapnia
1 sites across 1 states
Missouri1

This trial hasn't published a contact. View it on ClinicalTrials.gov

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Eligibility criteria

Exclusion

Pregnancy
Obtundation, or Coma
Confusion, Delirium, or Dementia
Unable to understand or carry out commands regarding keeping still and breathing pattern
Increased intracranial pressure due to space occupying lesion or obstruction of outflow of CSF
Claustrophobia
History of kidney problems
Pace makers
Skin tattoos
Neurostimulators (TENS-unit)
Implanted drug infusion device (i.e., insulin pump)
Exposure of metal fragments to your eye
Artificial heart valves
Aneurysm clips
Cochlear implants
Metallic implants and prosthesis
Vascular stent or stent graft
History as a metal worker
Shrapnel or bullet wounds
Dorsal column stimulators
  • Cerebral Oxygen MetabolismFrom the beginning of the MRI scan to the completion of the MRI scan -- 75 minutes.