Observational Study of OCT in Fuchs' Dystrophy

This is an observational study looking at how a special imaging test called Optical Coherence Tomography (OCT) can help us understand and predict changes in your vision if you have Fuchs' Dystrophy or Pseudophakic Bullous Keratopathy (a condition where the cornea swells after cataract surgery). Researchers will use OCT to measure swelling and cloudiness in your cornea (the clear front part of your eye) over a period of up to two years. The goal is to see if these measurements can help predict how your vision might change after eye surgery. You may be able to join if you are 18 or older, have damaged corneal endothelium (the inner layer of the cornea) from Fuchs' or PBK, and are willing to attend study visits. We don't know the current recruitment status.

Study design
This is an observational study, meaning researchers will watch and record information without giving any specific treatments. It aims to enroll 60 participants.
What's involved
You would need to commit to required study visits. The study will measure changes in your eye for up to two years.
Compensation
Not stated in the trial record.
Follow-up
Your corneal edema and haze will be measured for up to 2 years.

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NCT04258787

OCT in Fuchs' Dystrophy

Recruiting
Not specifiedAges 18+Observational
Oregon Health and Science University
~60 participants
Updated 2025-09-09 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Corneal Epithelial Edema/Haze
Measured over up to 2 years
+1 more outcome measured
Fuchs Dystrophy
Pseudophakic Bullous Keratopathy
1 sites across 1 states
Oregon1
  • Winston Chamberlain, MD, PhD · PRINCIPAL_INVESTIGATOR · Oregon Health and Science University

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Eligibility criteria

Inclusion

Damaged or diseased corneal endothelium from Fuchs' or PBK
Willingness to commit to required study visits

Exclusion

Prior Endothelial Keratoplasty (EK) or any other surgery except uncomplicated cataract surgery
Presence of a condition that increases the probability for treatment failure (e.g., heavily vascularized cornea, uncontrolled uveitis)
Other primary endothelial dysfunction conditions (e.g., posterior polymorphous corneal dystrophy and congenital hereditary corneal dystrophy, iridocorneal endothelial syndrome)
Central sub-epithelial or stromal scarring that could impact post-operative clarity assessment
Peripheral anterior synechiae in the angle greater than 3 clock hours
Hypotony
Uncontrolled glaucoma
Visually significant optic nerve or macular pathology
  • Corneal Epithelial Edema/Hazeup to 2 years

    OCT will be used to measure corneal epithelial edema/haze (in microns) in participants with Fuchs' or PBK

  • Corneal Stromal Edema/Hazeup to 2 years

    OCT will be used to measure corneal stromal edema/haze (in microns) in participants with Fuchs' or PBK