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[18F]Fluoropropyl-Trimethoprim ([18F]F-TMP) PET/CT Imaging for Bacterial Infections

This study is testing a new imaging drug called [18F]fluoropropyl-trimethoprim ([18F]F-TMP). This drug is given before a PET/CT scan (a type of imaging procedure) to help doctors see how it travels through your body and where it collects in areas of bacterial infection. The goal is to understand how [18F]F-TMP moves and is absorbed in people with known or suspected bacterial infections. You may be able to join if you are at least 18 years old and have a known or suspected bacterial infection. The study aims to enroll 20 participants.

Study design
This is an interventional study planning to enroll 20 participants. It is designed to understand how the imaging drug [18F]F-TMP is distributed and taken up in the body.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The study will look at the uptake of [18F]F-TMP in PET/CT scans over 3 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04263792

[18F]Fluoropropyl-Trimethoprim ([18F]F-TMP) PET/CT Imaging to Evaluate Biodistribution and Kinetics in Human Subjects

Recruiting
PHASE1Ages 18+Interventional
University of Pennsylvania
~20 participants
Updated 2026-02-05 on ClinicalTrials.gov
What's tested:[18F]fluoropropyl-trimethoprim

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Understand the biodistribution of F-TMP in human patients by looking at the F-TMP uptake in PET/CT scans
Measured over 3 year
+1 more outcome measured

Conditions

Bacterial Infections

Explore related trials

Bacterial Infection

Where it's being run

1 sites across 1 states
Pennsylvania1

Study leadership

  • Daniel Pryma, MD · PRINCIPAL_INVESTIGATOR · University of Pennsylvania

Who to contact

Erin Schubert
[email protected]
215-662-3041
Email the study team

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Eligibility criteria

Inclusion

At least 18 years of age
Known or suspected bacterial infection, per clinical documentation of suspected infection (e.g. lab results, pathology results, physician progress notes, clinical symptoms of infection)
Able to understand the investigational nature of this study and provide written informed consent in accordance with institutional and federal guidelines prior to study-specific procedures

Exclusion

Antibiotic therapy with trimethoprim within 48h of the baseline PET/CT scan
Inability to tolerate imaging procedures, in the opinion of an investigator or treating physician
Unstable or other severe medical or psychological comorbidities that would compromise the subject's safety or successful participation in the study, in the opinion of an investigator or treating physician
Pregnant or breast feeding patients; a urine pregnancy test will be performed in women of child-bearing potential prior to \[18F\]F-TMP injection, to confirm non-pregnant status

What this trial measures

  • Understand the biodistribution of F-TMP in human patients by looking at the F-TMP uptake in PET/CT scans3 year

    Understand the biodistribution of F-TMP in human patients by comparing the F-TMP uptake using maxSUV and meanSUV of each ROI which will be drawn manually in tissues of interest including but not limited to: Blood pool, heart muscle, brain, thyroid, lymph nodes, lung, liver, kidney, small bowel, large bowel, adrenal gland, pancreas, gall bladder, bone, muscle, and gonads.

  • Understanding the kinetics of uptake of [18F]F-TMP in human patients by looking at the F-TMP uptake in PET/CT scans3 years

    Understanding the the kinetics of uptake of \[18F\]F-TMP in human patients by comparing the F-TMP uptake using maxSUV and meanSUV of each ROI which will be drawn manually in tissues of interest including but not limited to: Blood pool, heart muscle, brain, thyroid, lymph nodes, lung, liver, kidney, small bowel, large bowel, adrenal gland, pancreas, gall bladder, bone, muscle, and gonads.