Forced Oscillometry in Infants With Bronchopulmonary Dysplasia

This study is looking at a new way to measure lung function in infants, especially those born prematurely with bronchopulmonary dysplasia (BPD), a chronic lung condition. It uses a non-invasive device called forced oscillometry (FOT) to measure how well their lungs are working. This device gently sends small air pulses into the lungs through a mask while the baby breathes normally. Researchers want to see if FOT can accurately measure lung function before and after babies receive bronchodilator therapy, a common treatment for BPD. You might be able to join if your baby is premature with BPD and breathing room air or low oxygen, or if your baby is a full-term infant without lung disease and less than 4 weeks old. The study aims to enroll 80 infants, but its current status is unclear.

Study design
This is an observational study, meaning researchers will be watching and measuring without giving new treatments. It plans to include 80 infants.
What's involved
Your baby will have a cushioned mask placed on their face to measure lung function while they are lying down and breathing regularly. This measurement will be taken before and, for some, after bronchodilator therapy.
Compensation
Not stated in the trial record.
Follow-up
Measurements are taken at specific times: prior to bronchodilator therapy, and 30 to 60 minutes following bronchodilator therapy for those already receiving it.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04270045

Forced Oscillometry in Infants With Bronchopulmonary Dysplasia

Recruiting
Not specifiedAll AgesObservational
Winston Manimtim
~80 participants
Updated 2026-01-21 on ClinicalTrials.gov
What's tested:Non-invasive forced airway oscillometry

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Forced oscillation technique measurements
Measured over FOT measurement prior to bronchodilator therapy
+1 more outcome measured
Infant, Premature, Diseases
Bronchopulmonary Dysplasia
Respiratory Distress Syndrome

NCT04270045

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Children's Mercy Hospital

    Kansas City, Missouristudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

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Eligibility criteria

Inclusion

Premature infants with BPD who are in room air based on the (per NICHD definition)
Premature infants with BPD who are receiving low flow O2 support and able to maintain normal spO2 in Room air for brief period ( up to 3 minutes) Term Cohort without pulmonary disease
Infants \>36 weeks gestational age without pulmonary disease
Infants \< 4 weeks of age
Former preterm infants \< 32 weeks at birth
Those with BPD based on NIH 2001 definition
Seen prior to 2 years of age

Exclusion

Infants with BPD requiring invasive or non-invasive positive pressure ventilation
Infants with BPD who have associated genetic diagnosis or major congenital anomalies.
  • Forced oscillation technique measurementsFOT measurement prior to bronchodilator therapy

    Baseline FOT measurements in premature infants with BPD and term infants without pulmonary disease.

  • Post-bronchodilator forced oscillation technique measurements (in subjects already receiving this therapy)FOT measurement 30 to 60minutes following bronchodilator therapy

    FOT measurements in premature infants with BPD following bronchodilator therapy.