Comparing Preparations for Heart Scans
This study is looking for healthy adults, aged 18 and older, who do not have a history of heart disease, diabetes, or chronic liver/kidney disease. The purpose is to find the best way to prepare for an FDG PET/CT scan, which is a test used to check for heart inflammation. Currently, a ketogenic diet (high fat, low carbohydrate) and fasting are used to reduce sugar uptake in the heart during the scan. This study will compare three different preparation methods: a ketogenic diet, a Ketone Drink, and a third method (implied by the study design). Researchers will use FDG PET/CT scans to measure how much sugar is taken up by the heart after each preparation. The goal is to see which method most effectively suppresses glucose in the heart. The study's current status is unclear.
- Study design
- This interventional study plans to enroll 20 healthy participants. It will compare the effects of a Ketogenetic Diet versus a Ketone Drink on myocardial glucose suppression.
- What's involved
- You will undergo three FDG PET/CT scans. For one scan, you will consume a Ketone Drink after a 12-hour fast. For another, you will follow a Ketogenetic Diet.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary endpoint, comparing myocardial glucose suppression, will be measured at 3 years.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Comparison of the Short-Term Effect of Dietary Carbohydrate Restriction Versus Exogenous Ketone Supplementation on Myocardial Glucose Suppression and Timing to Achieve a State of Ketosis Using FDG PET/CT Serial Imaging
At a glance
Conditions
Where it's being run
1 sites across 1 statesWho to contact
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What this trial measures
- Comparing the myocardial glucose suppression in Ketogenetic diet vs. external Ketone supplement by looking at the FDG uptake using PET/CT3 years
Comparing the myocardial glucose suppression in Ketogenetic diet vs. external Ketone supplement by looking at the FDG uptake using PET/CT. Images will be qualitative and semi-quantitatively assessed. The entire right and left ventricular walls will be contoured in a dedicated nuclear medicine workstation (MIM Software) to create volume of interest s(VOI) and derive the maximum and mean standardized uptake value (SUV) and total glycolytic activity (TGA), all measures of glucose utilization. Blood pool activity within the left ventricular cavity will be used as reference. Complete myocardial suppression will be defined as FDG activity (by any measure) in the left ventricular wall lower than blood pool activity in the ventricular cavity.