Understanding Substance Effects in Smokers
This study, called "Effects of a Specific Substance in Smokers," is looking for 60 people who smoke cigarettes or e-cigarettes occasionally. It aims to understand how different substances, like depressants (such as alcohol), stimulants (such as caffeine), or analgesics, affect brain function, impulsivity, and cigarette cravings in young adults. You would receive either the Study Agent (a legal, non-prescription substance) or a Placebo (a substance with no or very small amounts of the Study Agent) through drinks or capsules. Researchers will measure impulsivity, brain activity (using fMRI), and cigarette craving after you take the substance. To join, you must be 21-40 years old, right-handed, fluent in English, and have smoked 1-27 days in the past month. The study's goal is to help develop better ways to help young adults quit smoking.
- Study design
- This is an interventional study planning to enroll 60 participants. Participants will receive either the Study Agent or a Placebo.
- What's involved
- You would consume beverages and/or capsules containing the Study Agent or Placebo. Measurements of impulsivity, brain activity, and cigarette craving will be taken at specific times after consumption.
- Compensation
- Not stated in the trial record.
- Follow-up
- The study will assess how substance-induced changes predict cigarette use over the course of 1 year.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Effects of a Specific Substance in Smokers
At a glance
Conditions
Where it's being run
1 sites across 1 statesWho to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- ImpulsivityImmediately after beverage/capsule consumption
Impulsivity will be measured by assessing behavior on a temporal discounting task.
- Resting State Functional Connectivity35 minutes after beverage/capsule consumption
Brain function will be measured while participants are resting using functional magnetic resonance imaging
- Cigarette Craving and Associated Brain Activation50 minutes after beverage/capsule consumption
Brain function will be measured using functional magnetic resonance imaging while participants complete a Craving Regulation Task
- Symptoms of Cigarette Dependence1 year follow-up from baseline
The Fagerström Test of Nicotine Dependence total score will be used to measure changes in cigarette dependence