Understanding Substance Effects in Smokers

This study, called "Effects of a Specific Substance in Smokers," is looking for 60 people who smoke cigarettes or e-cigarettes occasionally. It aims to understand how different substances, like depressants (such as alcohol), stimulants (such as caffeine), or analgesics, affect brain function, impulsivity, and cigarette cravings in young adults. You would receive either the Study Agent (a legal, non-prescription substance) or a Placebo (a substance with no or very small amounts of the Study Agent) through drinks or capsules. Researchers will measure impulsivity, brain activity (using fMRI), and cigarette craving after you take the substance. To join, you must be 21-40 years old, right-handed, fluent in English, and have smoked 1-27 days in the past month. The study's goal is to help develop better ways to help young adults quit smoking.

Study design
This is an interventional study planning to enroll 60 participants. Participants will receive either the Study Agent or a Placebo.
What's involved
You would consume beverages and/or capsules containing the Study Agent or Placebo. Measurements of impulsivity, brain activity, and cigarette craving will be taken at specific times after consumption.
Compensation
Not stated in the trial record.
Follow-up
The study will assess how substance-induced changes predict cigarette use over the course of 1 year.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04281979

Effects of a Specific Substance in Smokers

Recruiting
NAAges 21–40InterventionalBasic science
Oregon Health and Science University
~60 participants
Updated 2025-07-28 on ClinicalTrials.gov
What's tested:Study AgentPlacebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Impulsivity
Measured over Immediately after beverage/capsule consumption
+3 more outcomes measured
Smoking
1 sites across 1 states
Oregon1

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Participants must be 21-40 years old
Right-handed
Fluent in English
Report smoking cigarettes or e-cigarettes 1-27 days in the past month
Report binge drinking based on NIAAA criteria (5 or more drinks per occasion for males, 4 or more drinks per occasion for females) at least 1 time in the past 90 days without adverse incident

Exclusion

Seeking treatment for substance use (e.g. nicotine or alcohol use)
Moderate or Severe Nicotine Dependence
Current alcohol use disorder
Illicit substance use other than marijuana use in the past year
Marijuana use more than 10 times in the past year
Major neurological or medical illness - Significant head trauma - Current use of medication affecting the central nervous system
MRI contraindications (e.g. irremovable metal on the body or pregnancy)
  • ImpulsivityImmediately after beverage/capsule consumption

    Impulsivity will be measured by assessing behavior on a temporal discounting task.

  • Resting State Functional Connectivity35 minutes after beverage/capsule consumption

    Brain function will be measured while participants are resting using functional magnetic resonance imaging

  • Cigarette Craving and Associated Brain Activation50 minutes after beverage/capsule consumption

    Brain function will be measured using functional magnetic resonance imaging while participants complete a Craving Regulation Task

  • Symptoms of Cigarette Dependence1 year follow-up from baseline

    The Fagerström Test of Nicotine Dependence total score will be used to measure changes in cigarette dependence