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Study on Critical Thermal Environments for Older Adults

This study is looking for adults aged 18 and older to understand how temperature and humidity affect older adults' ability to stay cool. You'll exercise in different warm environments to help researchers find the limits where older bodies struggle to regulate temperature. A small group of older adults will also be re-tested after taking a low dose of aspirin (ASA) for 7 days. The main goal is to identify specific temperature and humidity levels that become dangerous for older adults, which will be measured over about one year. The study is currently unclear about its recruitment status.

Study design
This is an interventional study planning to enroll 190 participants. A subgroup of older adults will receive low-dose aspirin, while all participants will have a control (no treatment) test.
What's involved
You will exercise in various environmental conditions. A subgroup of older adults will take low-dose aspirin for 7 days and then be re-tested.
Compensation
Not stated in the trial record.
Follow-up
Your core temperature will be measured through study completion, which is an average of 1 year.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04284397

Identification of Critical Thermal Environments for Aged Adults

Recruiting
EARLY_PHASE1Ages 18+InterventionalBasic science
Penn State University
~190 participants
Updated 2026-01-27 on ClinicalTrials.gov
What's tested:Low dose ASAControl

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Temperature and humidity limits for maintaining stable core temperature
Measured over Through study completion, an average of 1 year.

Conditions

Aging

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Aging

NCT04284397

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Noll Laboratory

    University Park, Pennsylvaniastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • W. Larry Kenney, Ph.D. · PRINCIPAL_INVESTIGATOR · The Pennsylvania State University

Who to contact

Lacy M Alexander, Ph.D.
[email protected]
8148671781
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

Adults aged 18 and older (those 40+ years of age must be cleared by collaborating physician)
All premenopausal women will be eumenorrheic (by survey)
Asymptomatic and no signs/symptoms of disease according to the American College of Sports Medicine 10th edition Guidelines for Exercise Testing and Prescription

Exclusion

Medications that affect thermoregulatory or cardiovascular responses to exercise
Any contraindications to low intensity physical activity on the Physical Activity Readiness Questionnaire
Any mobility restrictions that interfere with low intensity physical activity
Pregnant or planning to become pregnant in the next 12 months
Prior diagnosis of cancer, cardiovascular disease, diabetes, or metabolic syndrome
Illegal/recreational drug use
History of Chron's disease, diverticulitis, or similar gastrointestinal disease
Abnormal resting or exercise electrocardiogram (ECG)

What this trial measures

  • Temperature and humidity limits for maintaining stable core temperatureThrough study completion, an average of 1 year.

    Core temperature will be measured throughout exercise. The point at which heat stress becomes uncompensable will be determined for each environmental and exercise condition by assessing the combination of temperature and humidity at which core temperature begins to rise.