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Total Joint Arthroplasty in Children and Young Adults

This study is looking at how total joint replacement surgery (arthroplasty) affects the daily life and well-being of children and young adults. Researchers want to understand the long-term functional ability and quality of life for patients who have had a total knee or hip replacement for reasons other than cancer in the joint. This includes conditions like osteonecrosis (bone death due to lack of blood supply), trauma, infections, or birth defects. You may be able to join if you are between 10 and 25 years old and have had or will have a total joint replacement at Children's Hospital Colorado by Dr. Nathan Donaldson, Dr. Steven Thorpe, or previously by Dr. Travis Heare.

Study design
This is an observational study, meaning researchers will collect information without giving any specific treatments. The study plans to include 1000 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Researchers will collect information for up to 10 years after your surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04294693

Total Joint Arthroplasty in a Pediatric Population

Recruiting
Not specifiedAges 10–25Observational
University of Colorado, Denver
~1,000 participants
Updated 2026-04-20 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Standard of Care Data (routinely collected in clinic)
Measured over 10 years
+3 more outcomes measured

Conditions

Total Joint Arthroplasty

Explore related trials

Arthropathy

Where it's being run

1 sites across 1 states
Colorado1

Study leadership

  • Nathan Donaldson, DO · PRINCIPAL_INVESTIGATOR · Children's Hospital Colorado

Who to contact

Mia Lundin
[email protected]
720-777-4871
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age between 10 years and 25 years
Undergoing or have undergone total joint arthroplasty at Children's Hospital Colorado for non-solid tumor related reasons
Treated at Children's Hospital Colorado by Dr. Nathan Donaldson, DO or Dr. Steven Thorpe, MD or previously by Travis Heare, MD
Age between 10 years and 25 years
Treated at Children's Hospital Colorado by Dr. Nathan Donaldson, DO, or Dr. Steven Thorpe, MD or previously by Travis Heare, MD
Symptomatic joint pain treated non-invasively via lifestyle modifications, over the counter or prescription pain medication, nerve blocks or steroid injections, and/or physical therapy
Symptomatic joint pain treated via core decompression surgery at Children's Hospital Colorado by Dr. Nathan Donaldson, DO, or Dr. Steven Thorpe, MD, or previously by Travis Heare, MD

Exclusion

Subjects and/or parents not capable of completing basic questionnaires in English (HRQL data will not be collected from non-English speaking subjects because we do not have access to versions of these questionnaires that have been validated in languages other than English. These patients may be included at a later date when validated questionnaires are available).
Subjects who underwent hemiarthroplasties, failed rotationplasty to arthroplasty conversions, or joint arthroplasty directly related to a tumor at the location of the joint
Subjects diagnosed with mucopolysaccharidoses (MPS), pseudorheumatoid chondrodysplasia, or diastrophic dwarfism
Patients who underwent a joint arthroplasty directly related to a tumor at the location of the joint at Children's Hospital Colorado. Patients undergoing or have undergone total joint arthroplasty at Children's Hospital Colorado for non-solid tumor related reasons
Subjects diagnosed with mucopolysaccharidoses (MPS), pseudorheumatoid chondrodysplasia, or diastrophic dwarfism

What this trial measures

  • Standard of Care Data (routinely collected in clinic)10 years

    Demographic information such as specific diagnoses leading to joint degeneration, age at diagnosis, type of medical treatments leading to need for joint replacement, previous treatments for joint including surgeries, complications, etc.

  • Research Data: Health Related Quality of Life instrument10 years

    1\. Short Form-36 version 2 (SF-36v2)

  • Research Data: Health Related Quality of Life instrument10 years

    2\. Oxford 12 Questionnaire

  • Research Data: Health Related Quality of Life instrument10 years

    3\. Modified Harris Hip Score Questionnaire