This study is creating a registry (a research database) to learn more about two ways of taking tissue samples from your esophagus (the tube that carries food to your stomach). These methods are using forceps and using a brush to collect small tissue samples. The study will look at how the brush biopsy results affect your doctor's decisions about your future care. Researchers also want to see if either the brush biopsy, the forceps biopsy, or both can predict who with heartburn might develop Barrett's esophagus (a condition that can lead to cancer) or who with Barrett's esophagus might develop precancer or cancer. You can join if you are 18 or older, having an upper endoscopy with both types of biopsies as part of your standard care, and can understand and sign the consent form. The study will follow participants for 5 years.

Study design

This is an observational study, meaning researchers will collect data without giving you a specific treatment. It plans to include 90,000 participants.

What's involved

You will undergo an upper endoscopy with forceps and brush biopsies as part of your standard medical care. Your biopsy results will be recorded over 5 years.

Compensation

Not stated in the trial record.

Follow-up

Your biopsy results will be recorded over 5 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.