Study of Circulating Monocytes in Patients With Ischemic Vascular Disease

This observational study is looking at how certain white blood cells, called monocytes, and other substances in your blood react after a heart attack (myocardial infarction) or an ischemic stroke (a stroke caused by a blood clot). Researchers are particularly interested in a type of monocyte with a surface marker called "P2X4." They want to understand how these cells respond to injury in heart and brain tissue and if they produce chemicals that help with healing. The study aims to measure the levels of these monocytes and other related markers in patients at different times after a heart attack or stroke, comparing them to people with stable heart disease and healthy individuals. The main goal is to see if these measurements can help predict future heart attacks, strokes, or death over three years. This study is currently unclear on its recruitment status and plans to enroll 300 participants.

Study design
This is an observational study with no specified phase, involving 300 planned participants.
What's involved
You would provide three blood samples at different times: within 48 hours of hospital admission, 2-14 days later, and 30-120 days after a heart attack or stroke.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for three years to track hospitalizations for heart attack, stroke, or death.

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NCT04321512

Study of Circulating Monocytes in Patients With Ischemic Vascular Disease

Recruiting
Not specifiedAges 18+Observational
UConn Health
~300 participants
Updated 2026-08-17 on ClinicalTrials.gov
What's tested:There is no intervention given to the subjects

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Hospitalization for Myocardial Infarction, Stroke, or death
Measured over 3 years
Myocardial Infarction
Stroke, Ischemic
Ischemia
1 sites across 1 states
Connecticut1
  • Bruce Liang, MD · PRINCIPAL_INVESTIGATOR · UConn Health

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Eligibility criteria

Inclusion

STEMI Patients: Men and women aged 18 years and over, with symptoms, physical signs and ECG changes characteristic of STEMI.
NSTEMI Patients: Men and women aged 18 years and over, with symptoms, physical signs and ECG changes characteristic of NSTEMI.
Stable CAD Patients: men and women aged 18 years and older with coronary artery disease proven by prior MI history, angiography or stress test but without any unstable angina or acute coronary syndrome.
Ischemic Stroke Patients: Men and women aged 18 years and over, with symptoms, physical signs and CT/MRI changes characteristic of ischemic stroke.
Healthy Controls: Men and women aged 18 years and over, without heart failure, coronary disease, hypertension, diabetes or other chronic diseases. Control subjects will be recruited from within the community of UConn Health via advertisement.

Exclusion

Subjects who are unable to give informed consent (with the exception of the ischemic stroke arm patients, see Protocol Design below) and pregnant subjects.
Subjects who had any history of embolic, ischemic or hemorrhagic stroke within the last 12 months.
  • Hospitalization for Myocardial Infarction, Stroke, or death3 years

    myocardial infarction, stroke or death