Observational Study on Circulating Tumor DNA for Early Cancer Response

This study is looking at how circulating tumor DNA (ctDNA) can help detect cancer recurrence earlier in people with prostate, head and neck, esophageal, or genitourinary cancers, as well as healthy volunteers. ctDNA is tiny pieces of tumor DNA found in the blood. The study aims to see if earlier detection of cancer recurrence through ctDNA can lead to better treatment options and improved patient outcomes. Success in this study will be measured by how long participants remain free from cancer progression. The study is currently unclear on its recruitment status.

Study design
This is an observational study planning to enroll 100 participants. It is not testing a specific intervention or drug.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for freedom from progression through the completion of the study, estimated to be 6.5 years.

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NCT04354064

Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors

Recruiting
Not specifiedAges 18+Observational
Washington University School of Medicine
~100 participants
Updated 2026-02-20 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Freedom from progression
Measured over Through completion of study (estimated to be 6.5 years)
Healthy Volunteer
Prostate Cancer
Head and Neck Cancer
Esophageal Cancer
Genitourinary Cancer
Sarcoma
Breast Cancer
Colon Cancer
Gastrointestinal Cancer
Solid Tumor Cancer
Lung Cancer
Skin Cancer
Melanoma
1 sites across 1 states
Missouri1
  • Melissa Reimers, M.D. · PRINCIPAL_INVESTIGATOR · Washington University School of Medicine

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Eligibility criteria

Inclusion

Eligible healthy donors will be at least 18 years of age.

Exclusion

Healthy donors younger than 18 years of age
  • Freedom from progressionThrough completion of study (estimated to be 6.5 years)

    -Defined as RECIST 1.1 based radiographic or clinical progression, with non-progressors censored at last radiographic follow-up