SABER Study for Early Stage Breast Cancer
This study is testing a new way to give radiation therapy called Stereotactic Ablative Breast Radiotherapy (SABER) to women with early-stage breast cancer. The goal is to find the best dose of SABER to give before surgery, in a shorter amount of time. Researchers will be looking for the recommended dose of SABER within 13 weeks. To join, you must be a woman at least 50 years old with early-stage breast cancer that is ER/PR positive and HER2 negative. Your Oncotype or MammaPrint results are also needed. The study is currently unclear on its recruitment status and plans to enroll 18 participants.
- Study design
- This is an interventional study, meaning participants will receive a specific treatment. It aims to enroll 18 women.
- What's involved
- Participants will receive SABER radiation therapy in 5 sessions over 2 weeks, given on non-consecutive days. This will happen before standard partial mastectomy/axillary surgery.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary endpoint, finding the recommended dose, is measured up to 13 weeks.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
SABER Study for Selected Early Stage Breast Cancer
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Cristiane Takita, MD, MBA · PRINCIPAL_INVESTIGATOR · University of Miami
Who to contact
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What this trial measures
- Recommended Phase 2 Dose (RP2D) of Pre-Operative SABERUp to 13 Weeks
The recommended phase 2 dose (RP2D) of pre-operative SABER therapy will be established as the highest dose level tested for which no more than 1 out of 6 patients experience dose-limiting toxicity (DLT). Adverse Events (AEs) including DLTs will be evaluated by treating physician using the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) version 5.0