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The Olmsted NAFLD Epidemiology Study (TONES)

This study, called TONES, is looking at how common Non-Alcoholic Fatty Liver Disease (NAFLD) and Nonalcoholic Steatohepatitis (NASH) are in the community. Researchers want to understand these liver conditions better and create ways to diagnose them earlier. You might be eligible if you live in Olmsted County, are 18 or older, and haven't been diagnosed with NAFLD before. The study involves diagnostic tests like Magnetic Resonance Elastography (MRE), blood draws, and potentially a liver biopsy or Fibro Scan. The main goal is to find out the prevalence of NAFLD and NASH in the population over five years. The current recruitment status is unclear.

Study design
This is an interventional study planning to enroll 800 participants. It aims to understand the prevalence of NAFLD and NASH in the population.
What's involved
You would undergo diagnostic tests such as Magnetic Resonance Elastography (MRE) and blood draws. A liver biopsy or Fibro Scan may also be performed if indicated by MRE results.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, prevalence of NAFLD and NASH, will be measured at 5 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04365855

The Olmsted NAFLD Epidemiology Study (TONES)

Recruiting
NAAges 18+InterventionalDiagnostic
Mayo Clinic
~800 participants
Updated 2026-01-16 on ClinicalTrials.gov
What's tested:Magnetic Resonance ElastographyBlood drawLiver biopsyFibro Scan

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Prevalence of NAFLD and NASH in the population
Measured over 5 years

Conditions

Non-Alcoholic Fatty Liver Disease
Non-Alcoholic Steatohepatitis

Explore related trials

Nonalcoholic Fatty Liver DiseaseNonalcoholic Steatohepatitis

NCT04365855

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Mayo Clinic in Rochester

    Rochester, Minnesotano site contact published

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • ALINA M ALLEN, MD · PRINCIPAL_INVESTIGATOR · Mayo Clinic

Who to contact

Jodie A Cogswell
[email protected]
507-266-3995
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

Olmsted County residents at the time of search
Age 18 or older
No personal history of NAFLD diagnosis (administrative codes)

Exclusion

Alcohol in excess (more than 20 gm per week in women and 30 gm per week in men)
Currently pregnant
Have contraindications to MRI (MRI incompatible implanted devices, severe claustrophobia)

What this trial measures

  • Prevalence of NAFLD and NASH in the population5 years

    Number of subjects with NAFLD and NASH determined by the MRE