Normobaric Oxygen Therapy for First-Episode Psychosis

This study is testing if breathing extra oxygen (Normobaric Oxygen) can help individuals experiencing their first episode of psychosis. Researchers believe that improving oxygen supply to the brain might help with symptoms. You could be eligible if you are between 15 and 35 years old and have been diagnosed with a schizophrenia-spectrum disorder or mood disorder with psychotic features, and have had psychotic symptoms for less than 5 years. The study will look at whether Normobaric Oxygen improves your cognitive functioning (thinking skills), quality of life, and social functioning after 4 weeks. The current status of this study is unclear, and it plans to enroll 20 participants.

Study design
This is a single-blind, randomized controlled trial. This means you won't know if you're receiving the oxygen or a placebo, but the researchers will. It plans to include 20 participants.
What's involved
You would receive either Normobaric Oxygen or a placebo (room air) through a nasal cannula overnight for 4 weeks. After that, everyone will receive Normobaric Oxygen for another 4 weeks. Assessments will be done at the start, after 4 weeks, and after 8 weeks.
Compensation
Not stated in the trial record.
Follow-up
You will be followed for 8 weeks after enrollment, with assessments at 4 and 8 weeks.

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NCT04368039

Normobaric Oxygen Therapy for Individuals With First-Episode Psychosis

Recruiting
NAAges 15–35InterventionalTreatment
Nicholas Breitborde
~20 participants
Updated 2026-02-25 on ClinicalTrials.gov
What's tested:Normobaric OxygenPlacebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change from baseline in cognitive functioning
Measured over 4 weeks
+4 more outcomes measured
Psychosis
Schizophrenia
First-episode Psychosis
1 sites across 1 states
Ohio1

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  • Change from baseline in cognitive functioning4 weeks

    Change in scores on the MATRICS Consensus Cognitive Battery (MCCB).

  • Change from baseline in quality of life4 weeks

    Change in scores on WHO Quality of Life Scale Brief (WHOQOL-BREF.

  • Change from baseline in social functioning4 weeks

    Change in scores on the Global Functioning: Social Scale. Scores on this measure range from 1-10 with higher scores indicating greater social functioning

  • Change from baseline in role functioning4 weeks

    Change in scores on the Global Functioning: Role Scale. Scores on this measure range from 1-10 with higher scores indicative of greater role functioning.

  • Change from baseline in health-related quality of life4 weeks

    Change in scores on the RAND 36-Item Health Survey.