Virtual Histology of the Bladder Wall for Bladder Cancer Staging
This study is looking at a new way to use Magnetic Resonance Imaging (MRI) to help doctors understand how far bladder cancer has spread before surgery. You would have a special MRI scan where two contrast agents, Gadobutrol and Ferumoxytol, are placed into your bladder through a temporary catheter. Doctors will then compare these MRI images to what they find during your surgery to see how accurate the MRI is at determining the cancer's stage. This study is for people aged 18 to 90 who have a bladder tumor identified by cystoscopy (a procedure to look inside the bladder) and are scheduled for a TURBT (Transurethral Resection of Bladder Tumor) or have muscle-invasive bladder cancer and are scheduled for radical cystectomy (removal of the bladder). The study plans to enroll 42 participants, but its current status is unclear.
- Study design
- This is a Phase Ib interventional study involving 42 participants to test the safety and performance of a new MRI protocol.
- What's involved
- You would undergo a single MRI scan, which includes a pre-contrast image, instillation of a contrast solution into your bladder, and then a post-contrast image. This MRI would be performed 1 to 6 days before your scheduled surgery.
- Compensation
- Not stated in the trial record.
- Follow-up
- The accuracy of the MRI assessment will be measured at 4 weeks after tumor resection.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Virtual Histology of the Bladder Wall for Bladder Cancer Staging
At a glance
Conditions
NCT04369560
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
UPMC Hillman Cancer Center - Dept of Urology
Pittsburgh, Pennsylvaniastudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Jodi K Maranchie, MD · PRINCIPAL_INVESTIGATOR · Associate Professor
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Accuracy of Magnetic Resonance Imaging assessment of depth of bladder wall penetration to predict pathologic stage determined at tumor resection4 weeks
The assessment of clinical tumor stage assigned by the radiologist will be compared to the stage reported by the clinical pathologist following tumor resection to determine the overall accuracy of MRI for bladder cancer staging.