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NCT04385082

Cannabis Effects as a Function of Sex

Active, Not Recruiting
PHASE1Ages 21–55InterventionalBasic science
University of California, Los Angeles
~160 participants
Updated 2026-07-06 on ClinicalTrials.gov
What's tested:Active CannabisPlacebo Cannabis

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Subject-rated drug effects
Measured over 5 hours
+2 more outcomes measured

Conditions

Pain
Abuse, Drug

Explore related trials

Cannabis misuse

Where it's being run

1 sites across 1 states
California1

Study leadership

  • Ziva Cooper, PhD · PRINCIPAL_INVESTIGATOR · University of California, Los Angeles

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Male or non-pregnant female aged 21-55 years
Report use of cannabis an average of 1-7 days per week
Not currently seeking treatment for their cannabis use
Urine test positive for recent cannabis use for heavy users
No reported adverse effects with cannabis smoking in light users
Have a Body Mass Index from 18.5 - 34kg/m2.
Able to perform all study procedures
FEMALES: Currently practicing a non-hormonal effective form of birth control
FEMALES: Must be regularly cycling

Exclusion

Meeting DSM-V criteria for any substance use disorder other than nicotine, caffeine, or cannabis use disorder
Report using other illicit drugs in the prior 4 weeks
History or current evidence of severe psychiatric illness or medical condition judged by the study physician and PI to put the participant at greater risk of experiencing adverse events due to completion of study procedures, interfere with their ability to participate in the study, or their capacity to provide informed consent.
Current use of medical cannabis, prescription analgesics, or any medications that may affect study outcomes
Current pain
Insensitivity to the cold water stimulus of the Cold Pressor Test
FEMALES: using a hormonal contraceptive

What this trial measures

  • Subject-rated drug effects5 hours

    Average and peak subjective ratings of drug effects associated with abuse liability as measured using visual analogue scales (VAS; 1-100mm).

  • Analgesia as measured using the Cold Pressor Test5 hours

    Peak and average pain threshold and tolerance assessed using the Cold Pressor Test

  • Pharmacokinetics of THC and metabolites5 hours

    Plasma levels of THC, 11-OH-THC, and THCCOOH