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Observational Study on Glaucoma, Vision, and Life Space

This study is looking at how primary open-angle glaucoma (a common eye disease that can cause vision loss) and vision problems, especially in dim light, might affect how much older adults get out and about in their daily lives (their "life space"). Researchers will use questionnaires like the Life Space Questionnaire and the Low Luminance Questionnaire, and conduct vision tests such as Contrast sensitivity under dim illumination, Visual field under dim illumination (MAIA), and Macular Pigment Optical Density (MPOD). The goal is to see if there are differences in vision and life space between people with healthy eyes and those with glaucoma. You can join if you are between 18 and 100 years old and are already participating in one of two specific NIH-funded glaucoma studies.

Study design
This is an observational study aiming to enroll 100 participants. It compares people with healthy eyes to those with primary open-angle glaucoma.
What's involved
Participants will complete questionnaires and undergo various vision tests, including those for contrast sensitivity, visual field, and macular pigment density. These assessments will occur over an average of one year.
Compensation
Not stated in the trial record.
Follow-up
Participants will be assessed for an average of one year, through study completion.

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NCT04396002

Glaucoma, Visual Field Loss, and Their Association With Life Space in Older Adults

Recruiting
Not specifiedAges 18+Observational
University of Alabama at Birmingham
~100 participants
Updated 2025-09-12 on ClinicalTrials.gov
What's tested:Life Space QuestionnaireLow Luminance QuestionnaireContrast sensitivity under dim illuminationVisual field under dim illumination (MAIA)Macular Pigment Optical Density (MPOD)Dark Adaptation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Assessment of life space measured with the Life Space Questionnaire
Measured over Through study completion, an average of 1 year
+7 more outcomes measured

Conditions

Primary Open Angle Glaucoma

Explore related trials

Primary Open Angle Glaucoma

Where it's being run

1 sites across 1 states
Alabama1

Study leadership

  • Lyne Racette, PhD · PRINCIPAL_INVESTIGATOR · University of Alabama at Birmingham

Who to contact

Lyne Racette, PhD
[email protected]
205-325-8673
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Participants that are enrolled in the Early Detection of Glaucoma Progression using a Novel Individualized Approach (IRB-300000301) or in the African Descent and Glaucoma Evaluation (ADAGES) IV: Alterations of the Lamina Cribrosa in Progression (IRB-161115004).
No diagnosis of eye disease

Exclusion

Not being enrolled in one of the following two NIH-funded studies: 1. African Descent and Glaucoma Evaluation (ADAGES) IV: Alterations of the lamina cribrosa in progression (EY026574) or 2. Early detection of glaucoma progression using a novel individualized approach (EY025756)
Cognitive impairment that would preclude ability to take the tests

What this trial measures

  • Assessment of life space measured with the Life Space QuestionnaireThrough study completion, an average of 1 year

    The Life Space Questionnaire is a 9-item questionnaire that assesses how much a person gets out and about and the spatial extent of the person's typical life space, i.e., what is the usual range of places in which the person engages in activities within the designated time frame. Patients are asked to respond either Yes or No.

  • Assessment of vision under low luminance conditionsThrough study completion, an average of 1 year

    The Low Luminance Questionnaire is a 32-item questionnaire that assesses how participants see under dim illumination and how well they can perform different tasks (e.g. reading, driving). Patients are asked to select a response among different choices on a Likert scale that ranges from 1 to 5, 1 to 6, 1 to 7, or 1 to 8 depending on the question. A response of "1" indicates that the participant experiences no difficulty while increasingly higher numbers indicate increasing amounts of difficulty.

  • Differences in contrast sensitivity functions between controls and patientsThrough study completion, an average of 1 year

    Participants will be presented with targets of different spatial frequency at different contrasts. Their sensitivity at each spatial frequency will be recorded/

  • Differences in dark adaptation between controls and patientsThrough study completion, an average of 1 year

    Once participants have adapted to a dark environment, they will be exposed to a bright flash of light. The time needed to recover their visual sensitivity will be measured (rod-intercept time).

  • Differences in visual sensitivity under dim illumination between controls and patientsThrough study completion, an average of 1 year

    Participants will be presented with targets at different locations in their visual fields under dim illumination.

  • Differences in Macular Pigment Optical Density between controls and patientsThrough study completion, an average of 1 year

    Participants will fixate on a target while their MPOD is assessed. The MPOD is measured using the Heidelberg optical coherence tomography (OCT) MPOD module. Two different light sources are directed to the back of the eye. The light is reflected back and the OCT/MPOD computes the difference in the reflectance of the two lights which is an estimate of the density of macular pigment.

  • Assessment of the relationship between each the measure of visual function and life spaceThrough study completion, an average of 1 year

    The relationship between each of the measures of visual function (dark adaptation, contrast sensitivity functions, visual fields under dim illumination, and MPOD) and life space (Life Space Questionnaire will be assessed.

  • Assessment of the relationship between each the measure of visual function and self-reported visual function under dim illuminationThrough study completion, an average of 1 year

    The relationship between each of the measures of visual function (dark adaptation, contrast sensitivity functions, visual fields under dim illumination, and MPOD) and self-reported visual performance under dim illumination (Low Luminance Questionnaire) will be assessed.