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Combination Exercise for Fatigability in Veterans with Chronic Kidney Disease

This study is looking at how a combination exercise program, including Flywheel Resistance and Aerobic Exercise, affects tiredness (fatigability) in Veterans with chronic kidney disease (CKD) who are not yet on dialysis. You might be able to join if you are a Veteran between 50 and 85 years old, can walk, and have CKD stages 3 or 4 (meaning your kidney function, measured by eGFR, is between 15-59 ml/min). The study wants to see if this exercise helps reduce how tired you feel, improves your muscle strength in your knees, and changes blood flow to your muscles. The goal is to find ways to help Veterans with CKD feel less tired and improve their overall health.

Study design
This is an interventional study planning to enroll 30 participants. It compares an exercise program in people with CKD to a control group without kidney disease.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be assessed at week 6 and week 12 to measure changes in fatigability and muscle blood flow.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04397159

Effects of Combination Exercise on Fatigability in Veterans With Chronic Kidney Disease

Recruiting
NAAges 50–85InterventionalTreatment
VA Office of Research and Development
~30 participants
Updated 2026-03-12 on ClinicalTrials.gov
What's tested:Combination Exercise

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
change in knee extensor fatigability
Measured over week 6 and 12
+2 more outcomes measured

Conditions

Chronic Kidney Disease Predialysis

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Chronic Kidney Disease

NCT04397159

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Washington DC VA Medical Center, Washington, DC

    Washington D.C., District of Columbiastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Jared M. Gollie, PhD · PRINCIPAL_INVESTIGATOR · Washington DC VA Medical Center, Washington, DC

Who to contact

Jared M Gollie, PhD
[email protected]
(202) 745-8000
Email the study team

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Eligibility criteria

Inclusion

Ambulatory (with or without a gait aid), 50 years of age or older diagnosed with chronic kidney disease (CKD) stages 3 \& 4 predialysis (as defined by eGFR 59-15 ml/min per 1.73m2)
Control group will include ambulatory individuals without clinical evidence of kidney disease (defined by eGRF \>60 ml/min per 1.73m2) within the last 12-months
All participants must be able to speak and read English, and demonstrate orientation to person, place, and time

Exclusion

adults diagnosed with acute renal failure/injury within the last 12-months
non-ambulatory individuals
adults who do not use the DC VAMC as their main site for renal care
those who have any uncontrolled cardiovascular
musculoskeletal disease
or other conditions that, in the opinion of the principal investigator, could make participation in the study unsafe
any orthopedic or joint pain which would prevent the participant from safely engaging in the study protocol
additionally, individuals with plans to relocate from the DC metro area within one year will not be eligible for the intervention portion of the study

What this trial measures

  • change in knee extensor fatigabilityweek 6 and 12

    Knee extensor fatigability will be assessed as changes in torque of the dominant leg during 30 contractions.

  • change in perceived fatigabilityweek 6 and 12

    Rating of perceived fatigability will be assessed using a 10-point scale with 0 indicating "not fatigued at all" and 10 indicating "absolutely exhausted". Low scores reflect lower perceived fatigability.

  • change in muscle blood flowweek 6 and 12

    Muscle blood flow of the vastus lateralis will be assessed using near-infrared spectroscopy and determined as the change in total hemoglobin during venous occlusion test.