This study aims to understand how blood flow and metabolism affect brain development in children and young adults, especially those with Sickle Cell Anemia (SCA). Researchers will use Magnetic Resonance Imaging (MRI) to look at brain blood flow and how blood vessels expand and contract. During the MRI, participants will inhale Carbon Dioxide to measure how their brain's blood vessels react. The study is looking for 120 participants, including children with SCA and healthy children, aged 4 to 21 years. The main goal is to measure the thickness of the gray matter (the outer layer of the brain) after three years to see if there are differences, particularly in children with SCA who have had brain damage (infarcts). The study's current status is unclear.

Study design

This interventional study plans to enroll 120 participants, including children with Sickle Cell Anemia and healthy controls, who will be matched by age and sex.

What's involved

Participants will undergo an MRI scan while inhaling Carbon Dioxide to measure cerebrovascular reactivity.

Compensation

Not stated in the trial record.

Follow-up

Gray matter cortical thickness will be measured at 3 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.