Cognitive Training for Emotion Regulation in Psychotic Disorders

This study is testing a cognitive training program to help people with psychotic disorders better manage their emotions. It compares two types of training: "Emotional working memory training," which uses emotional tasks, and "Placebo working memory training," which uses non-emotional tasks. Researchers want to see if the emotional training can improve how your brain's prefrontal cortex (the front part of your brain involved in decision-making and emotion) works, leading to better emotion regulation. You might be able to join if you are 18-60 years old, have been diagnosed with schizophrenia or schizoaffective disorder, speak English, and have been stable on your antipsychotic medication. The study aims to enroll 70 participants, but its current recruitment status is unclear.

Study design
This interventional study plans to enroll 70 participants to compare two different behavioral training programs.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The main goal is to measure changes in brain activity from the start of the study to 15 or 30 days later.

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NCT04414215

Cognitive Training for Emotion Regulation in Psychotic Disorders

Recruiting
NAAges 18–60InterventionalTreatment
University of Georgia
~70 participants
Updated 2025-02-05 on ClinicalTrials.gov
What's tested:Emotional working memory trainingPlacebo working memory training

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Prefrontal blood oxygen level dependent activation in the prefrontal cortex
Measured over Change from baseline to 15 days or 30 days
Schizophrenia
Schizo Affective Disorder
1 sites across 1 states
Georgia1

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Eligibility criteria

Inclusion

diagnostic and statistical manual fifth edition diagnosis of schizophrenia or schizoaffective disorder
18-60 years old
speaks English
premorbid intelligence quotient \> 70
clinically stable as indicated by no antipsychotic medication changes in the last month or if on depot, no change in the past 2 months.

Exclusion

history of intellectual disability or neurological disorder
history of traumatic brain injury with loss of consciousness \> 10 minutes or behavioral sequelae
substance use disorder within the last 6 months (other than nicotine)
4\) endorsement of MRI exclusion factors
  • Prefrontal blood oxygen level dependent activation in the prefrontal cortexChange from baseline to 15 days or 30 days

    blood oxygen level dependent change in the prefrontal cortex as measured using functional magnetic resonance imaging. This will be calculated as a change from baseline to follow-up on the contrast score (unpleasant passive viewing condition - reappraisal) on the emotion regulation reappraisal task