Observational Study on Bioenergetic Phenotypes and Cardiometabolic Health in Children

This research study is looking at how daily activities, behaviors, and fitness affect the health of blood cells and their mitochondria (the powerhouses of cells that make energy). Researchers want to understand how these tiny energy makers in your cells are connected to body fat and how well you can exercise. The study is for healthy children aged 8 to 10 years old. To join, you must not have certain health conditions like severe asthma, autism, ADHD, or epilepsy. The main goal is to measure platelet mitochondrial respiration (how well mitochondria in blood cells use oxygen) and see how it relates to body fat and peak aerobic capacity (how much oxygen your body can use during exercise) in children. The study aims to enroll 300 participants, but its current recruitment status is unclear.

Study design
This is an observational study, meaning researchers will observe participants without providing any interventions. It plans to enroll 300 healthy children.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured at 8 days, suggesting a short follow-up period.

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NCT04427462

Bioenergetic Phenotypes and Cardiometabolic Health

Recruiting
Not specifiedAges 8–10Observational
Arkansas Children's Hospital Research Institute
~300 participants
Updated 2025-02-07 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Platelet mitochondrial respiration and its association with adiposity and peak aerobic capacity in children 8 to 10 years old.
Measured over 8 days
Healthy
1 sites across 1 states
Arkansas1
  • Elisabet Borsheim, Ph · PRINCIPAL_INVESTIGATOR · Arkansas Children's Nutrition Center

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Eligibility criteria

Exclusion

Opposition defiant disorder
conduct disorder
epilepsy
chronic kidney disease
hormonal disease
autoimmune diseases
bleeding disorders
chronic infections
mental health disorder
Type 2 and Type 1 diabetes
Other pre-existing medical conditions or medications as determined by the investigators to affect the outcomes of interest
  • Platelet mitochondrial respiration and its association with adiposity and peak aerobic capacity in children 8 to 10 years old.8 days

    Platelet mitochondrial respiration from isolated platelets will be measured using a flux analyzer. Adiposity will be measured with dual X-ray absorptiometry, and peak aerobic capacity with an incremental cycle ergometer test. measure physical activity