Study on AGXT Gene and Kidney Stones
This study is looking at how a specific gene change (a heterozygous mutation of the AGXT gene) affects how much oxalate (a substance that can form kidney stones) your body makes, especially if you've had calcium oxalate kidney stones before. You would eat a controlled low oxalate diet for five days. Researchers will measure the amount of oxalate in your urine to see if this gene change affects it. To join, you need to be at least 18 years old, have a history of calcium oxalate kidney stones, and have the specific AGXT gene mutation confirmed by an Invitae Nephrolithiasis Panel test. Pregnant or breastfeeding individuals cannot participate. The study is currently unclear on its recruitment status.
- Study design
- This is an interventional study with a planned enrollment of 4 participants. It is not specified if it is randomized or blinded.
- What's involved
- You would need to follow a controlled low oxalate diet for five days and provide blood and urine samples.
- Compensation
- Not stated in the trial record.
- Follow-up
- Urinary oxalate excretion will be measured from baseline through Day 4. It is not specified if there is follow-up after this period.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Heterozygous Individuals for AGXT and Kidney Stones
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Kyle Wood, MD · PRINCIPAL_INVESTIGATOR · University of Alabama at Birmingham
Who to contact
This trial hasn't published a contact. View it on ClinicalTrials.gov
Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Urinary Oxalate ExcretionBaseline through Day 4
Urinary oxalate excretion from urine samples will be measured as mg/day