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Spermatogonial Stem Cell Transplant and Testicular Tissue Grafting for Infertility

This study is testing two procedures, Spermatogonial Stem Cell Transplant and Testicular Tissue Grafting, to help men who are infertile due to cancer or autoimmune disorders. These procedures aim to restore sperm production using testicular tissue or cells that were frozen before treatments like chemotherapy or radiation. You might be able to join if you are a male, have reached a certain stage of puberty (Tanner stage 3 or higher), have previously frozen testicular tissue/cells, and are healthy enough for anesthesia. The main goal is to see how many participants start producing sperm again within 3 months to 1 year after the procedure. The study is currently unclear about its recruitment status and plans to enroll 10 participants.

Study design
This is an interventional study, meaning participants will receive a specific treatment. It aims to enroll 10 male participants.
What's involved
Participants will undergo Spermatogonial Stem Cell Transplant and Testicular Tissue Grafting procedures. They will also need to be healthy enough for anesthesia.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed to measure the return of spermatogenesis (sperm production) between 3 months and 1 year after the procedure.

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NCT04452305

Spermatogonial Stem Cell (SSC) Transplant and Testicular Tissue Grafting

Recruiting
NAAll AgesInterventionalTreatment
University of Pittsburgh
~10 participants
Updated 2026-04-22 on ClinicalTrials.gov
What's tested:Spermatogonial Stem Cell Transplant and Testicular Tissue Grafting

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Number of participants with return of spermatogenesis
Measured over 3 months-1year

Conditions

Infertility, Male
Cancer
Autoimmune Disorder

Explore related trials

Infertility

Where it's being run

1 sites across 1 states
Pennsylvania1

Study leadership

  • Kyle E Orwig, PhD · PRINCIPAL_INVESTIGATOR · University of Pittsburgh

Who to contact

Jennifer L Anglin
[email protected]
412-641-7475 · ext. 1
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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Male participant at least in Tanner stage 3
Previously cryopreserved and stored testicular tissue/cells (frozen due to an infertility-risking diagnosis or treatment such as chemotherapy or radiation) available for autologous transplantation and grafting
Healthy enough to undergo anesthesia
Written clearance for the procedure from the patient's hematologist or oncologist to confirm the patient has finished treatment for primary condition and are clear to undergo autologous stem cell transplant

Exclusion

Participants considered to be high risk for surgical complications
Participants with a history of leukemia, lymphoma or testicular cancer or a cancer that likely involved testicles at the time of testicular tissue collection
Diagnosed with psychological, psychiatric, or other conditions which prevent giving fully informed consent.

What this trial measures

  • Number of participants with return of spermatogenesis3 months-1year

    Rate of participants where sperm was found in semen analysis or testicular tissue analysis