Understanding Atopic Dermatitis Severity and the IL-4Ra R576 Polymorphism

This study is looking into whether a specific genetic difference, called the IL-4Ra R576 polymorphism, is linked to more severe atopic dermatitis (a type of eczema). Researchers want to see if this genetic difference is connected to changes in your body's immune system and the types of microbes on your skin. You can join if you are 6 to 65 years old and have atopic dermatitis. The study will measure the severity of your atopic dermatitis at the beginning of the study. The current recruitment status is unclear.

Study design
This is an observational study, meaning researchers will observe participants without providing any specific intervention. It plans to include 111 participants.
What's involved
You would have one visit where questionnaires, a blood draw, a skin swab, and skin biopsies would be performed.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

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NCT04455906

Mechanisms of Increased Disease Severity in AD Patients With the IL-4Ra R576 Polymorphism

Recruiting
Not specifiedAges 6–65Observational
Boston Children's Hospital
~111 participants
Updated 2026-05-18 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
atopic dermatitis severity
Measured over baseline, only 1 time point
Atopic Dermatitis
1 sites across 1 states
Massachusetts1
  • Wanda Phipatanakul, MD. MS. · PRINCIPAL_INVESTIGATOR · Boston Children's Hospital

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  • atopic dermatitis severitybaseline, only 1 time point

    validated assessment EASI score