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Transcranial Magnetic Stimulation for Progressive Supranuclear Palsy

This study is investigating if repetitive transcranial magnetic stimulation (rTMS) can help improve balance problems in people with Progressive Supranuclear Palsy (PSP). rTMS is a non-invasive (does not involve surgery) treatment that uses magnetic fields to stimulate brain cells. Researchers believe that by targeting a specific part of the brain called the cerebellum, rTMS might reduce unsteadiness. To join, you should be between 40 and 85 years old, have probable or possible PSP, and be able to stand unassisted for at least 30 seconds and walk with a walker. The study will measure balance using objective posturography (a way to measure your balance) over an 8-week period to see if the treatment is successful. The current recruitment status is unclear, and the study plans to enroll 30 participants.

Study design
This is an interventional study with a planned enrollment of 30 participants. The study aims to see the effects of rTMS on balance in people with PSP.
What's involved
You would be assessed on 4 days during an 8-week study period. Specific procedures beyond rTMS and posturography are not detailed.
Compensation
Not stated in the trial record.
Follow-up
Your balance will be assessed over an 8-week period.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04468932

Transcranial Magnetic Stimulation in Progressive Supranuclear Palsy

Recruiting
NAAges 40–85InterventionalTreatment
Oregon Health and Science University
~30 participants
Updated 2025-05-29 on ClinicalTrials.gov
What's tested:Repetitive transcranial magnetic stimulation (rTMS)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
objective posturography
Measured over assessed on 4 days during the 8 week study period

Conditions

Palsy Supranuclear
Supranuclear Palsy, Progressive

Explore related trials

Progressive Supranuclear Palsy

Where it's being run

1 sites across 1 states
Oregon1

Study leadership

  • Marian L Dale, MD, MCR · PRINCIPAL_INVESTIGATOR · Oregon Health and Science University

Who to contact

Graham Harker
[email protected]
5034182601
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

probable or possible PSP by the revised MDS PSP Criteria (Hoglinger 2017)
age 40-85 at time of screening
ability to understand and cooperate with simple instructions in English
ability to read at 6th grade reading level in English
ability to stand unassisted for at least 30 seconds and to be able walk independently with a walker
ability to refrain from new physical and speech therapy programs for the duration of the study
ability to remain on stable doses of any cholinergic, dopaminergic, serotonergic sedative or NMDA receptor antagonists for the duration of the study
females of child-bearing age must perform a urine pregnancy test and be on reliable birth control during the course of the study

Exclusion

other significant neurological or vestibular disorders
presence of electrically, magnetically or mechanically activated implants or history of injurious metal exposure in eyes, head, or body

What this trial measures

  • objective posturographyassessed on 4 days during the 8 week study period

    The primary endpoint is center of pressure shifts with tilt and with translation, and body sway in quiet stance.