Study of Mosaic Embryo Transfer for Infertility

This study is looking at the results of transferring a "mosaic embryo" (an embryo with both normal and abnormal cells) into the uterus of women experiencing infertility. The goal is to see how often these embryos lead to a successful pregnancy and a live birth. You might be able to join if you are a woman between 18 and 45 years old, have completed an IVF cycle with genetic testing (PGT) at the Colorado Center for Reproductive Medicine (CCRM), and have a mosaic embryo that you are willing to transfer. The study will measure the implantation rate (how often the embryo attaches to the uterus) at 3-4 weeks and the live birth rate at 9-12 months after the embryo transfer. The current recruitment status is unclear.

Study design
This is an interventional study that plans to enroll 250 women. It is a prospective study, meaning researchers will follow participants forward in time.
What's involved
You would undergo a procedure to transfer a mosaic embryo to your uterus. The study will evaluate implantation at 3-4 weeks and live birth at 9-12 months after the transfer.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 9-12 months after embryo transfer to assess live birth rates.

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NCT04472156

A Prospective Study of a Mosaic Embryo Transfer

Recruiting
NAAges 18–45InterventionalTreatment
Colorado Center for Reproductive Medicine
~250 participants
Updated 2024-02-29 on ClinicalTrials.gov
What's tested:Transfer of mosaic embryo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Evaluation of Implantation rate
Measured over 3-4 weeks after embryo transfer
+1 more outcome measured
Infertility
1 sites across 1 states
Colorado1
  • Mandy Katz-Jaffe, PhD · PRINCIPAL_INVESTIGATOR · Fertility Genetics

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Eligibility criteria

Inclusion

Women age 18-45 Infertile women who have completed an IVF cycle with PGT at the Colorado Center for Reproductive Medicine (CCRM) that have a mosaic embryo
Patients can be of any race, culture, sexual orientation or ethnicity
Patients that are willing to transfer a single embryo

Exclusion

Patients that do not meet the clinical requirements for an embryo transfer per clinic standards.
Patients that desire more than a single embryo transfer.
Patients that are using a gestational carrier.
Embryonic mosaic PGT results that include chromosome errors 13, 18, 21
Patients that did not complete their IVF with PGT cycle at the Colorado Center for Reproductive Medicine.
  • Evaluation of Implantation rate3-4 weeks after embryo transfer

    Ultrasound will be performed 2-3 weeks after initial positive pregnancy test to confirm viable pregnancy as evidenced by gestational sac in the uterus with a fetal heat rate

  • Live birth rate9-12 months post embryo transfer

    Live birth rate will be evaluated