Aspirin for Preeclampsia Postpartum

This study is looking at whether a daily low dose of aspirin (81 mg) can help women who have had preeclampsia after giving birth. Preeclampsia is a serious condition during pregnancy that causes high blood pressure and can affect organs. Researchers want to see if aspirin can lower certain levels in your blood called Activin A, which are often high in women with preeclampsia. They also want to see if aspirin improves heart function (measured by something called GLS percentages). You could be eligible if you are a pregnant woman between 18 and 45 years old, diagnosed with preeclampsia, and are expecting one baby. The study aims to enroll about 180 participants. The current status of the study is unclear, meaning it might not be actively recruiting right now.

Study design
This is a single-center study where participants are randomly assigned to receive either aspirin or a placebo (an inactive pill) without knowing which they are getting. It is designed to compare the effects of these treatments.
What's involved
If you join, you would take a daily pill (either aspirin or placebo) starting at your first visit and continuing for up to 6 months. You would also have two blood draws: one when you are admitted for delivery and another at your 6-month postpartum visit.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 6 months after starting the study treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04479072

Aspirin and Preeclampsia

Recruiting
PHASE4Ages 18–45InterventionalPrevention
University of Chicago
~180 participants
Updated 2026-05-04 on ClinicalTrials.gov
What's tested:Aspirin 81 mgPlacebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Difference in Activin A levels
Measured over 6 Months
+1 more outcome measured
Preeclampsia Postpartum
1 sites across 1 states
Illinois1

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  • Difference in Activin A levels6 Months

    The primary outcome will compare Activin A levels at 6 months between patients randomized to aspirin therapy versus placebo and the observational group.

  • GLS percentages6 months

    The primary outcome will compare GLS levels as a percentage (%) at 6 months between patients randomized to aspirin therapy versus placebo and the observational group.