University of Iowa Interventional Psychiatry Service Patient Registry for Depression and OCD
This study is a registry collecting information from patients receiving treatments for severe depression (Treatment-Resistant Depression, Major Depressive Episode, Major Depression, Major Depressive Disorder, Bipolar Disorder) or Obsessive-Compulsive Disorder (OCD). The treatments being studied include Electroconvulsive Therapy (ECT), Transcranial Magnetic Stimulation (TMS), Ketamine infusions, Esketamine nasal spray, and Deep Transcranial Magnetic Stimulation (dTMS). Researchers want to see how well these treatments work by measuring changes in your depression symptoms using the Montgomery-Åsberg Depression Rating Scale (MADRS) or OCD symptoms using the Yale-Brown Obsessive Compulsive Scale. You can join if you are between 18 and 99 years old and can speak English. The study aims to enroll 1000 participants.
- Study design
- This is an observational study, meaning researchers will collect information about your treatment without assigning you to a specific one. It aims to include 1000 participants.
- What's involved
- You would undergo one of the specified treatments. Assessments will be taken within about one week before starting treatment and again as close as possible after treatment completion, usually 4-6 weeks later.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your symptoms will be assessed approximately 4-6 weeks after completing your treatment course.
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University of Iowa Interventional Psychiatry Service Patient Registry
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Mark J Niciu, M.D., Ph. D. · PRINCIPAL_INVESTIGATOR · University of Iowa Hospitals & Clinics
- Nicholas T Trapp, M.D., M.S. · PRINCIPAL_INVESTIGATOR · University of Iowa Hospitals & Clinics
Who to contact
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What this trial measures
- Montgomery-Åsberg Depression Rating Scale (MADRS) Pre-Post ChangePre-assessment will be obtained within approximately 1 week of starting treatment. Post-assessment will be obtained as close as possible following completion of treatment course (usually 4-6 weeks later).
For patients with TRD, the MADRS will be administered. The MADRS contains 10 items, and each item is scored 0-6. These item scores are summed to create a scale score; thus, scale scores range from 0 to 60. A scale score of 0 indicates the absence of depressive symptoms, while a score of 60 indicates severe depression. The primary outcome is the mean change in total MADRS score. A decrease in the mean MADRS score indicates a decrease (or improvement) in depressive symptoms, whereas an increase in the mean MADRS score indicates an increase (or worsening) in depressive symptoms.
- Yale-Brown Obsessive Compulsive ScalePre-assessment will be obtained within approximately 1 week of starting treatment. Post-assessment will be obtained as close as possible following completion of treatment course (usually 4-6 weeks later).
For patients with OCD, the YBOCS will be administered. Questions on the YBOCS examine the amount of time spent thinking and acting on obsessions and compulsions, how much impairment or distress is caused, and how much resistance and control the participant has over their thoughts or behavior.