The Hepatitis C Transplant Collaborative

This study is looking at the safety and outcomes for people who receive a heart transplant from a donor who had hepatitis C (HCV NAT+ donor organs). Researchers want to see if using these donor hearts, along with new treatments for hepatitis C, leads to good results for patients. You could join if you are 18 or older and have received a heart from a donor who tested positive for hepatitis C. This includes people who are having a re-transplant. The study will measure how many people get a heart transplant from an HCV NAT+ donor, how many are cured of hepatitis C, and the rate of primary graft dysfunction (when the new heart doesn't work well right away). The study is currently unclear on its status and plans to enroll 500 participants.

Study design
This is an observational study, meaning researchers will watch and collect information without giving specific treatments. It plans to include 500 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for up to 6.5 years to assess cure rates and for 30 days to assess primary graft dysfunction.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04493385

The Hepatitis C Transplant Collaborative

Recruiting
Not specifiedAges 18+Observational
Baylor Research Institute
~500 participants
Updated 2026-01-22 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Number of donor HCV nucleic-acid testing positive (HCV NAT+) cardiac transplantation
Measured over 6.5 years
+5 more outcomes measured
Transplant; Failure, Heart
Hepatitis C
1 sites across 1 states
Texas1
  • Shelley A Hall, MD FACC · PRINCIPAL_INVESTIGATOR · BSWRI

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  • Number of donor HCV nucleic-acid testing positive (HCV NAT+) cardiac transplantation6.5 years

    To assess the current status of donor HCV NAT+ cardiac transplantation via retrospective data collection.

  • Failure versus Cure Rate for HCV NAT+ Heart Transplants6.5 years

    sustained viral response (SVR)-12 (cure-rate) for HCV negative recipient

  • Rate of Primary graft dysfunction (PGD)30 days

    Rate of Expected Post-Transplant Risks

  • 1 year mortality1 Year

    Number of deaths

  • Cellular graft rejection rate6.5 years

    Graft rejection rate

  • Antibody Mediated Rejection rate6.5 years

    Graft rejection rate