Stress Reduction for Heart Inflammation Study

This study is looking at whether an 8-week stress reduction program can help reduce inflammation in the arteries (blood vessels) of people who have atherosclerosis (a condition where plaque builds up inside your arteries) and high levels of stress. The program uses mind-body techniques to help you learn how to identify and manage stress. Researchers will measure changes in arterial inflammation using a special imaging scan called a PET scan (positron emission tomography) after 2 months. You may be able to join if you are between 30 and 65 years old, identify as having increased stress, and have a Perceived Stress Scale (PSS) score greater than 5. The study aims to enroll 30 participants.

Study design
This is a randomized controlled imaging study. Participants will be assigned by chance to either the stress reduction program or a group with no intervention. This study plans to enroll 30 participants.
What's involved
You would undergo baseline imaging, participate in an 8-week stress reduction program if assigned to that group, and then have follow-up imaging approximately 12 weeks after randomization.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for approximately 12 weeks after randomization, with arterial inflammation measured at 2 months.

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NCT04496947

Pilot Study Evaluating the Impact of Stress Reduction on Atherosclerotic : Heart and Mind Study

Recruiting
NAAges 30–65Interventional
Massachusetts General Hospital
~30 participants
Updated 2026-06-03 on ClinicalTrials.gov
What's tested:Stress Reduction

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in arterial inflammation by PET
Measured over 2 months
Atherosclerosis
Stress
Inflammation
1 sites across 1 states
Massachusetts1
  • Ahmed Tawakol, MD · PRINCIPAL_INVESTIGATOR · MGH

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Eligibility criteria

Inclusion

• Aged between 30-65 years
Identifies as having increased levels of stress and/or has a Perceived Stress Scale (PSS) score \>5 at baseline, and is interested in participating

Exclusion

Perceived Stress Scale (PSS) score \<6
  • Change in arterial inflammation by PET2 months

    Change in arterial inflammation based on FDG PET - from initial imaging to repeat imaging.