NCT04499248
AGN-193408 SR in the Treatment of Open-angle Glaucoma or Ocular Hypertension
Active, Not Recruiting
PHASE1Ages 18+InterventionalTreatmentAbbVie
~100 participants
Updated 2026-05-22 on ClinicalTrials.gov
What's tested:AGN-193408 SRLumiganSham AdministrationLumigan Vehicle
At a glance
Recruiting sites
0 of 49 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change from Baseline in Hour 0 Intraocular Pressure (IOP) in the Study Eye
Measured over Baseline to Month 36
+1 more outcome measured
Conditions
Where it's being run
49 sites across 27 statesCalifornia7
Florida6
Missouri3
Tennessee3
Georgia2
Indiana2
New Jersey2
North Carolina2
Study leadership
- ABBVIE INC. · STUDY_DIRECTOR · AbbVie
Who to contact
This trial hasn't published a contact. View it on ClinicalTrials.gov
Do you actually qualify for this trial?
Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.
Eligibility criteria
Inclusion
Participant is willing to withhold his/her IOP (Intraocular Pressure) treatments according to the study requirements, and in the opinion of the investigator, can do so without significant risk.
Diagnosis of either OAG \[open-angle glaucoma\] (ie, \[POAG\], pseudoexfoliation glaucoma,pigmentary glaucoma) or OHT (ocular hypertension) in both eyes.
Must be pseudophakic (at least 4 months postcataract surgery prior to treatment administration \[Cycle 1 Day 1 Administration visit\]) (Cohort 3 only).
Exclusion
Known allergy or sensitivity to any study medication or its components, any component of the delivery vehicle, procedure-related materials, or diagnostic agents used during the study (eg, topical anesthetic, dilating drops, fluorescein, povidone-iodine).
Concurrent or anticipated enrollment in an investigational drug or device study or participation in such a study within 2 months prior to the Baseline visit through the final study visit.
History of intracameral implant in the study eye (eg, Bimatoprost SR, OTX-TIC, ENV515 Travoprost XR).
History of laser trabeculoplasty within 6 months prior to screening in the study eye.
History or evidence of clinically relevant, substantial ocular trauma (eg, a traumatic cataract, traumatic angle recession, etc.) in the study eye.
History or evidence of complicated cataract/lens surgery, as stated in the protocol.
Intraocular surgery (including cataract surgery) in the study eye within the 4 months prior to treatment administration.
Any history of corneal graft, including partial grafts (eg, Descemet's Stripping Endothelial Keratoplasty \[DSEK\], Descemet's Membrane Endothelial Keratoplasty \[DMEK\]); or incisional refractive surgery (eg, radial keratotomy), other than astigmatic keratotomy or limbal relaxing incisions in the study eye.
History of herpetic ocular diseases in either eye (including herpes simplex virus and varicella zoster virus).
Anticipated need for any incisional or laser ocular surgery in either eye during the study.
History of anatomically narrow angle resulting in evidence of angle changes or any history or closed angle glaucoma in the study eye.
History or evidence of a peripheral iridotomy/iridectomy in the inferior iris in the study eye.
Any history of trabeculectomy or other types of incisional glaucoma surgery, including a glaucoma seton or aqueous bypass stents in either eye, or minimally invasive glaucoma surgery (MIGS) type trabecular meshwork surgeries in the study eye.
Anticipated use of corticosteroids in either eye except for permitted interventions or systemically during the study, or historical use prior to Baseline within:
3 years: intraocular fluocinolone acetonide
6 months: intraocular corticosteroid(s) other than fluocinolone; any injectable periocular or sub-Tenon's/subconjunctival corticosteroid
2 months: systemic (eg, oral, intramuscular, intravenous) or topical ocular corticosteroids
2 weeks: dermal corticosteroids applied to skin of the eyelid(s), around the eye, or adnexa.
Anticipated use of other topical ocular medications in either eye except for permitted interventions.
The anticipated wearing of contact lenses in the study eye (Cohort 1) and both eyes (Cohorts 2 and 3) during the study that deviates from the following (contact lens wear is allowed during the study, but is to be temporarily discontinued before study visits, and before and after an Administration Day according to the following):
Use of soft lenses should be discontinued at least 3 days prior to Baseline, and use of rigid gas permeable or hard contact lenses should be discontinued at least 1 week prior to Baseline
Use of soft lenses should be discontinued at least 3 days and use of rigid gas permeable or hard contact lenses should be discontinued at least 1 week prior to a scheduled study visit or Administration Day visit
Use of contact lenses of any kind should be discontinued for 1 week following any AGN-193408 SR administration
Central corneal thickness of \< 480 or \> 620 micrometers in both eyes.
Visual field loss in the study eye that, in the opinion of the investigator, is functionally significant (eg, split fixation, field defect within the central 10 degrees that is visually significant or likely to cause central visual impairment upon progression) or shows evidence of progressive visual field loss within the year prior to Baseline.
Evidence of macular edema in either eye during screening or in participant's medical history.
At Screening, evidence of posterior synechia behind the iris inferiorly in the study eye that in the investigator's opinion may inhibit the ability to safely receive at least 1 AGN-193408 SR implant (Cohort 3 only).
What this trial measures
- Change from Baseline in Hour 0 Intraocular Pressure (IOP) in the Study EyeBaseline to Month 36
IOP is a measurement of the fluid pressure inside the study eye. A negative change from baseline indicates an improvement and a positive change from baseline indicates a worsening.
- Number of participants experiencing treatment emergent adverse eventsBaseline to Month 36