Raised Head of Bed for High Blood Pressure When Lying Down in Autonomic Failure
This study is looking at whether raising the head of your bed can help lower high blood pressure that occurs when you're lying down (supine hypertension), a common issue for people with autonomic failure (a condition where the nervous system doesn't control body functions well). Researchers are testing different ways to elevate the head of the bed, either by tilting the whole bed or just raising the trunk, by 8, 9, or 12 inches. The main goal is to see if these methods can reduce your systolic blood pressure (the top number in a blood pressure reading) overnight or during short sessions. This approach works by using gravity to decrease the amount of blood returning to your heart, which may help lower blood pressure. The study is open to adults aged 18-85 with autonomic failure and supine hypertension, but excludes pregnant women and those with certain serious health conditions. About 44 people are expected to join.
- Study design
- This interventional study plans to enroll 44 participants. It is not specified if the study is randomized or blinded.
- What's involved
- Participants will have their blood pressure measured overnight (10 PM to 8 AM) or during acute sessions (1 hour at each head elevation).
- Compensation
- Not stated in the trial record.
- Follow-up
- Blood pressure is measured overnight (10 PM to 8 AM) or during acute sessions (1 hour at each elevation of the head).
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Effect of Raised Head of the Bed on Lying Blood Pressure in Autonomic Failure
At a glance
Conditions
NCT04502225
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
Vanderbilt University Medical Center
Nashville, Tennesseestudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Italo Biaggioni, MD · PRINCIPAL_INVESTIGATOR · Vanderbilt University Medical Center
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
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Inclusion
Exclusion
What this trial measures
- Systolic Blood Pressure10 PM to 8 AM
Maximal change from baseline in systolic blood pressure during the night
- Systolic Blood Pressure10 PM to 8 AM or acute session (1 hour at each elevation of the head)
Difference in systolic blood pressure between tilt and elevated trunk sessions