This study aims to understand how ulcers heal in people with inflammatory bowel disease (IBD) compared to those without IBD. Researchers will compare non-healing ulcers in IBD patients with healing biopsy sites in healthy individuals and patients with rheumatoid or psoriatic arthritis. You may be eligible if you have ulcerative colitis or Crohn's disease and are starting anti-TNF therapy, or if you have rheumatoid or psoriatic arthritis and are already on anti-TNF therapy, or if you are a healthy control. The study involves taking biopsies during colonoscopies to look at gene expression and mitochondrial function, hoping to find patterns related to ulcer healing. The goal is to see changes in mitochondrial DNA and specific gene expression levels after about 35 days. The current recruitment status is unclear, and the study plans to enroll 60 participants.

Study design

This is an interventional study involving three groups of participants. It is not specified if it is randomized or blinded, but it aims to enroll 60 participants.

What's involved

You would undergo an initial colonoscopy where 16-20 extra biopsies are taken, and the sites are marked. You would then return for a follow-up colonoscopy 4-35 days later for another 16-20 biopsies from the same sites.

Compensation

Not stated in the trial record.

Follow-up

Participants will be followed for at least 35 days, which is when the primary endpoints are measured.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.